Active Recombinant Human GZMB Protein, His-tagged

• Cat.No.: GZMB-40H
• Product Overview: Recombinant Human GZMB Protein, fused to His-tag, was expressed in Baculovirus.

Specification

• Description: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT.
• Bio-activity: Specific activity is > 7,000pmol/min/ug, and is defined as the amount of enzyme that cleave 1pmole of Boc-Ala-Ala-Asp-SBzl at 37C.
• Molecular Mass: 26.5 kDa (235aa)
• Protein Length: 19-247aa
• Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
• Purity: > 95% by SDS-PAGE
• Applications: SDS-PAGE, Enzyme Activity
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at 2 centigradeto 8 centigrade for 1 week. For long term storage, aliquot and store at -20 centigrade to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by absorbance at 280nm)

Gene Information

• Gene Name: GZMB granzyme B [ Homo sapiens (human) ]
• Official Symbol: GZMB
• Synonyms: C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
• Gene ID: 3002
• mRNA Refseq: NM_004131.6
• Protein Refseq: NP_004122.2
• MIM: 123910
• UniProt ID: P10144