Active Recombinant Human IFNL1 Protein

• Cat.No.: IFNL1-047H
• Product Overview: Recombinant human interleukin-29 carries a mutation of Cys171 (which does not participate in disulfide bonding) in the wild-type IL-29 protein, while retaining the disulfide bonds Cys15-Cys112 and Cys49-Cys145.

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
• Form: Sterile lyophilized powder
• Molecular Mass: ~20.0 kDa
• Bio-activity: Activity is determined by the HepG2 cytopathic-effect inhibition assay, with an ED50 of < 20 ng/mL.
• Endotoxin: <1 EU/μg determined by LAL.
• Purity: ≥97%
• Storage: Lyophilized samples remain stable for more than 6 months from the date of receipt when stored at –20 to –70 centigrade. Avoid repeated freeze–thaw cycles.
• Storage Buffer: This product is supplied as a sterile lyophilized powder in a buffer containing PBS, 5% trehalose, and 0.01% Tween-80, pH 7.4.
• Reconstitution: Before opening the vial, centrifuge at 10, 000 rpm for 30–60 seconds, or at 3, 000 rpm for 5 minutes, then reconstitute with 0.2 mL of sterile water.

Gene Information

• Gene Name: IFNL1 interferon lambda 1 [ Homo sapiens (human) ]
• Official Symbol: IFNL1
• Synonyms: IFNL1; interferon lambda 1; IL29; IL-29; interferon lambda-1; IFN-lambda-1; cytokine Zcyto21; interleukin 29 (interferon, lambda 1); interleukin-29
• Gene ID: 282618
• mRNA Refseq: NM_172140
• Protein Refseq: NP_742152
• MIM: 607403
• UniProt ID: Q8IU54