Active Recombinant Human KDM4D, FLAG-tagged

• Cat.No.: KDM4D-52H
• Product Overview: Recombinant Human KDM4D (accession number NP_060509.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 63.2 kDa.

Specification

• Description: KDM4D (lysine (K)-specific demethylase 4D), also known as JMJD2D (Jumonji Domain Containing 2D) is a protein that functions as a histone demethylase that preferentially demethylates di- and trimethylated lysine 9 residues of histone H3, while it has no activity on monomethylated H3K9 residues.
• Source: Sf9 insect cells
• Species: Human
• Tag: FLAG
• Form: 25 mM HEPES, pH 7.5, 150 mM NaCl and 5% glycerol.
• Bio-activity: H3K9me3 demethylase.
• Applications: Enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
• Concentration: 0.8 mg/ml

Gene Information

• Gene Name: KDM4D lysine (K)-specific demethylase 4D [ Homo sapiens ]
• Official Symbol: KDM4D
• Synonyms: KDM4D; lysine (K)-specific demethylase 4D; JMJD2D, jumonji domain containing 2D; lysine-specific demethylase 4D; FLJ10251; jumonji domain containing 2D; jumonji domain-containing protein 2D; jmjC domain-containing histone demethylation protein 3D; JMJD2D; MGC141909
• Gene ID: 55693
• mRNA Refseq: NM_018039
• Protein Refseq: NP_060509
• MIM: 609766
• UniProt ID: Q6B0I6
• Chromosome Location: 11q21
• Function: metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen