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Active Recombinant Human KDR Protein, Fc-tagged, Alexa Fluor 488 conjugated

Cat.No. : KDR-5442HAF488
Product Overview : Alexa Fluor 488 conjugated recombinant human KDRwas fused with the Fc part of human IgG1. The recombinant mature KDRis a disulfide-linked homodimeric protein. The KDR monomers have a mass ofapproximately 160 kDa.
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Description : KDR has a lower affinity for VEGF than theFlt-1 receptor, but a higher signaling activity. Mitogenic activity inendothelial cells is mainly mediated by KDR leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted,soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted formsof KDR have so far been reported. The binding of VEGF165 to KDR is dependenton heparin.
Source : Insect cells
Species : Human
Tag : Fc
Form : Lyophilized
Bio-activity : The activity of KDR was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effectis typically 10-30 ng/mL.
Molecular Mass : 160 kDa
Endotoxin : < 0.1 ng/ μg of KDR
Purity : > 90 % by SDS-PAGE and analyzed by silver stain
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 488 via amines
Excitation Wavelength: 488 nm
Emission Wavelength: 515­-545 nm
Storage : Lyophilizedsamples are stable for greater than six months at -20 to -70 centigrade. Reconstituted KDR should be stored in working aliquots at -20 centigrade. Avoidrepeated freeze-thaw cycles.
Reconstitution : The lyophilized KDRis soluble in water and most aqueous buffers. The lyophilized KDR should bereconstituted in PBS or medium to a concentration not lower than 50 μg/mL.
Gene Name : KDR kinase insert domain receptor (a typeIII receptor tyrosine kinase) [ Homo sapiens ]
Official Symbol : KDR
Synonyms : KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; solubleVEGFR2; OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor
Gene ID : 3791
mRNA Refseq : NM_002253
Protein Refseq : NP_002244
MIM : 191306
UniProt ID : P35968

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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