Active Recombinant Human KDR Protein, Fc-tagged, Alexa Fluor 488 conjugated
Cat.No. : | KDR-5442HAF488 |
Product Overview : | Alexa Fluor 488 conjugated recombinant human KDRwas fused with the Fc part of human IgG1. The recombinant mature KDRis a disulfide-linked homodimeric protein. The KDR monomers have a mass ofapproximately 160 kDa. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | KDR has a lower affinity for VEGF than theFlt-1 receptor, but a higher signaling activity. Mitogenic activity inendothelial cells is mainly mediated by KDR leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted,soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted formsof KDR have so far been reported. The binding of VEGF165 to KDR is dependenton heparin. |
Source : | Insect cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized |
Bio-activity : | The activity of KDR was determined by its ability to inhibit the VEGF-dependent proliferation of human umbilical vein endothelial cells. The ED50 for this effectis typically 10-30 ng/mL. |
Molecular Mass : | 160 kDa |
Endotoxin : | < 0.1 ng/ μg of KDR |
Purity : | > 90 % by SDS-PAGE and analyzed by silver stain |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Storage : | Lyophilizedsamples are stable for greater than six months at -20 to -70 centigrade. Reconstituted KDR should be stored in working aliquots at -20 centigrade. Avoidrepeated freeze-thaw cycles. |
Reconstitution : | The lyophilized KDRis soluble in water and most aqueous buffers. The lyophilized KDR should bereconstituted in PBS or medium to a concentration not lower than 50 μg/mL. |
Gene Name : | KDR kinase insert domain receptor (a typeIII receptor tyrosine kinase) [ Homo sapiens ] |
Official Symbol : | KDR |
Synonyms : | KDR; kinase insertdomain receptor (a type III receptor tyrosine kinase); FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; solubleVEGFR2; OTTHUMP00000158928; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factorreceptor |
Gene ID : | 3791 |
mRNA Refseq : | NM_002253 |
Protein Refseq : | NP_002244 |
MIM : | 191306 |
UniProt ID : | P35968 |
Products Types
◆ Recombinant Protein | ||
KDR-01H | Recombinant Human KDR Protein (20-764aa), C-hIgG-His tagged | +Inquiry |
KDR-477R | Recombinant Rhesus macaque KDR Protein, His-tagged | +Inquiry |
Kdr-81M | Recombinant Mouse Kdr Protein, His (Fc)-Avi-tagged | +Inquiry |
KDR-475H | Recombinant Human KDR Protein, His-tagged | +Inquiry |
KDR-1084H | Recombinant Human KDR protein(Met1-Lys327), His-tagged | +Inquiry |
◆ Lysates | ||
KDR-417HCL | Recombinant Human KDR cell lysate | +Inquiry |
KDR-1769HCL | Recombinant Human KDR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1609 | KDR Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All KDR Products
Required fields are marked with *
My Review for All KDR Products
Required fields are marked with *
0
Inquiry Basket