Active Recombinant Human LAG3 protein, Fc-tagged
Cat.No. : | LAG3-1830H |
Product Overview : | Human LAG3, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Leu 450 (Accession # NP_002277.4). |
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Description : | Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Leu 23 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Bio-activity : | Immobilized Human LAG-3, Fc Tag at 2μg/mL (100 μL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL. |
Molecular Mass : | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.3 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | AA Leu 23 - Leu 450 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. No activity loss is observed after storage at: 4-8°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | LAG3 lymphocyte activating 3 [ Homo sapiens (human) ] |
Official Symbol : | LAG3 |
Synonyms : | CD223; lymphocyte-activation gene 3 |
Gene ID : | 3902 |
mRNA Refseq : | NM_002286.5 |
Protein Refseq : | NP_002277.4 |
UniProt ID : | P18627 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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