Active Recombinant Human LGALS8 Protein (Met2-Trp317), N-His tagged, Animal-free, Carrier-free
Cat.No. : | LGALS8-194H |
Product Overview : | Recombinant Human LGALS8 Protein (Met2-Trp317) with N-His tag was expressed in E. coli and Animal-free as well as Carrier-free. |
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Description : | Galectin-8 (Gal-8) is a lectin family member and is one of the tandem repeat-type galectins containing two carbohydrate recognition domains (CRD) connected by a linker region in a single peptide chain. The CRD is responsible for β-galactoside binding, and the binding partners for galectin-8 have been identified, including CD44 and a subset of integrins. Galectin-8 and integrins form complexes, subsequently leading to phosphorylation of paxillin and focal adhesion kinase (FAK), which activates signal pathways including MAPK-ERK and PI3K-AKT pathways. Galectin-8 is constitutively presented in the Liver, kidney, cardiac muscle, lung, and brain. Galectin-8 serves as an immunosuppressive protective role against autoimmune CNS inflammation, regulating the balance of Th17 and Th1 polarization. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is < 8 μg/mL. |
Molecular Mass : | The protein has a calculated MW of 36.6 kDa. The protein migrates as 34 kDa under reducing condition (SDS-PAGE analysis). |
Protein length : | Met2-Trp317 |
Endotoxin : | < 0.1 EU/μg of the protein by the LAL method. |
Purity : | >98% as determined by SDS-PAGE analysis. |
Storage : | This product is stable after storage at: -20 centigrade for 12 months in lyophilized state from date of receipt. -20 or -80 centigrade for 1 month under sterile conditions after reconstitution. Avoid repeated freeze/thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved. |
Shipping : | The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage. |
Gene Name : | LGALS8 lectin, galactoside-binding, soluble, 8 [ Homo sapiens (human) ] |
Official Symbol : | LGALS8 |
Synonyms : | LGALS8; lectin, galactoside-binding, soluble, 8; galectin-8; galectin 8; PCTA 1; galectin-8g; Po66 carbohydrate binding protein; po66 carbohydrate-binding protein; prostate carcinoma tumor antigen 1; Gal-8; PCTA1; PCTA-1; Po66-CBP; |
Gene ID : | 3964 |
mRNA Refseq : | NM_006499 |
Protein Refseq : | NP_006490 |
MIM : | 606099 |
UniProt ID : | O00214 |
Products Types
◆ Recombinant Protein | ||
LGALS8-3624H | Recombinant Human LGALS8 | +Inquiry |
LGALS8-1090C | Recombinant Cattle LGALS8 Protein, His-tagged | +Inquiry |
LGALS8-2323R | Recombinant Rhesus Macaque LGALS8 Protein, His (Fc)-Avi-tagged | +Inquiry |
Lgals8-3776M | Recombinant Mouse Lgals8 Protein, Myc/DDK-tagged | +Inquiry |
LGALS8-5178H | Active Recombinant Human LGALS8 protein(Met1-Trp317), GST-tagged | +Inquiry |
◆ Lysates | ||
LGALS8-4762HCL | Recombinant Human LGALS8 293 Cell Lysate | +Inquiry |
LGALS8-4763HCL | Recombinant Human LGALS8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewExpertise shines, supports research progress.
Top-notch analysis, highly recommended for research projects.
Reliable data source, a research necessity.
Q&As (7)
Ask a questionLGALS8 is involved in immune system modulation, influencing immune cell activation and response.
LGALS8 interacts with a range of proteins, participating in diverse signaling pathways and cellular functions.
Genetic mutations in LGALS8 can lead to altered cell signaling, impacting various biological processes.
It plays a role in apoptosis regulation, affecting cell survival and death mechanisms.
Altered LGALS8 activity is associated with cancer development, influencing tumor cell survival and metastasis.
Targeting LGALS8 offers potential for treating diseases, including cancer, by modulating key cellular processes.
LGALS8, a galectin protein, is involved in modulating cell communication, particularly in cell-cell and cell-matrix interactions.
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