Active Recombinant Human NSD1 protein, GST-tagged
Cat.No. : | NSD1-03H |
Product Overview : | Recombinant Human NSD1 protein, fused to GST-tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Multiple transcript variants encoding distinct isoforms have been identified for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | 25 mM Tris, pH 7.4,150 mM NaCl and 5% glycerol. |
Bio-activity : | H3K36 and H4K20 methyltransferase |
Molecular Mass : | 51 kDa |
Protein length : | 1852-2082aa |
Purity : | >95% |
Applications : | Recombinant NSD1-SET protein is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
Storage : | Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation.Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
Expiry : | 6 months |
Concentration : | 1.0 mg/ml |
Gene Name : | NSD1 nuclear receptor binding SET domain protein 1 [ Homo sapiens (human) ] |
Official Symbol : | NSD1 |
Synonyms : | STO; KMT3B; SOTOS; ARA267; SOTOS1 |
Gene ID : | 64324 |
mRNA Refseq : | NM_022455 |
Protein Refseq : | NP_071900 |
MIM : | 606681 |
UniProt ID : | Q96L73 |
Products Types
◆ Recombinant Protein | ||
NSD1-035H | Recombinant Human NSD1 Protein, GST-tagged | +Inquiry |
NSD1-002H | Recombinant Human NSD1 Protein, GST-tagged | +Inquiry |
NSD1-82H | Recombinant Human NSD1, GST-tagged | +Inquiry |
NSD1-143H | Recombinant Human NSD1 Protein, His-tagged | +Inquiry |
NSD1-2813H | Recombinant Human NSD1 protein, His-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1787 | NSD1 Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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