Species : |
Human |
Source : |
Human Cells |
Description : |
Oncostatin M (OSM) is a 30 kDa secreted cytokine belonging to the Interleukin 6 family. OSM inhibits the proliferation of a number of tumor cell lines. It also stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM plays crucial roles in inflammation, neuroprotection, hematopoiesis, metabolism and development. |
Bio-activity : |
The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line). |
Molecular Mass : |
30 kDa homotrimer |
Endotoxin : |
<0.5 EU/ μg |
Purity : |
High Purity, >95% by SDS-PAGE |
Stability : |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -80 centigrade under sterile conditions after reconstitution. |
Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution in PBS without carrier protein |
Reconstitution : |
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |