Active Recombinant Human Phosphoglucose Isomerase

• Cat.No.: PGI-32H
• Product Overview: Active Recombinant Human Phosphoglucose Isomerase without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
• Form: Clear liquid
• Bio-activity: 250 U/mg
• Purity: ≥ 95% by SDS-PAGE
• Stability: At least 2 years
• Storage: Store it at -20 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 6.2 mg/mL

Gene Information

• Gene Name 2: GPI glucose-6-phosphate isomerase [ Homo sapiens (human) ]
• Official Symbol 2: GPI
• Synonyms 2: GPI; glucose-6-phosphate isomerase; AMF; NLK; PGI; PHI; GNPI; SA36; SA-36; CNSHA4; glucose-6-phosphate isomerase autocrine motility factor hexose monophosphate isomerase hexosephosphate isomerase neuroleukin oxoisomerase phosphoglucose isomerase phosphohexomutase phosphohexose isomerase phosphosaccharomutase sperm antigen-36 EC 5.3.1.9
• Gene ID 2: 2821
• mRNA Refseq 2: NM_000175
• Protein Refseq 2: NP_000166
• MIM 2: 172400
• UniProt ID 2: P06744