Active Recombinant Human PIP4K2B protein, GST-tagged

• Cat.No.: PIP4K2B-168H
• Product Overview: Recombinant Human PIP4K2B fused with an N-terminal GST tag was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase, type II, beta) catalyzes the phosphorylation of phospha-tidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. PIP4K2B is a member of the phosphatidylinositol-5-phosphate 4-kinase family. PIP5K2B interacts specifically with the juxtamembrane region of the p55 TNF receptor and that PIP5K2B activity is increased in mammalian cells by treatment with TNF-alpha. PIP5P4KB plays a role in determining insulin sensitivity and adiposity.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 5250 nmol/min/mg
• Molecular Mass: 73 kDa
• Purity: >95%
• Applications: Kinase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta [ Homo sapiens ]
• Official Symbol: PIP4K2B
• Synonyms: PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; phosphatidylinositol 4 phosphate 5 kinase, type II, beta , PIP5K2B; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; PIP5KIIB; PIP5KIIbeta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; PI5P4KB; PIP5K2B
• Gene ID: 8396
• mRNA Refseq: NM_003559
• Protein Refseq: NP_003550
• MIM: 603261
• UniProt ID: P78356
• Chromosome Location: 17q21.2
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Phosphatidylinositol signaling system, organism-specific biosystem; Phosphatidylinositol signaling system, conserved biosystem
• Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; nucleotide binding; receptor signaling protein activity; transferase activity