Active Recombinant Human PVR Homodimer Protein, His tagged

• Cat.No.: PVR-28H
• Product Overview: CD155 dimer protein contains a CD155 extracellular domain (Uniprot# P15151) fused with a proprietary dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 21-343 aa
• Description: Human CD155 (cluster of differentiation 155) is a cell-surface type I transmembrane glycoprotein that belongs to the Nectin/Nectin-like family. It is also known as Poliovirus Receptor (PVR), HVED, NECL5, Necl-5, PVS, TAGE4, and FLJ25946. It consists of three extracellular immunoglobulin-like (Ig-like) domains (D1-D3), one transmembrane region, and a C-terminal cytoplasmic domain. CD155 is widely expressed on various cell types and often overexpressed on cancer cells. CD155 dimerization has emerged as an important factor in various diseases, especially cancer, poliovirus infection, and autoimmune disorders. Upregulation of CD155 in several types of human cancers is associated with a poor prognosis. Although CD155 itself is not an immune checkpoint, it's a ligand for checkpoint receptors like TIGIT (T-cell immunoreceptor with Ig and ITIM domains), CD226 (DNAM-1), and CD96. The interactions between CD155 and its receptors on immune cells modulate immune responses, such as T cells and natural killer (NK) cells. This makes CD155 a critical player in immune regulation and a promising target in checkpoint cancer therapies.
• Molecular Mass: 150 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for CD155-specific antibody and TIGIT protein binding assays. SPR & BLI for CD155-specific antibody and TIGIT protein binding assays. Suggested Applications: ELISA for CD155-specific antibody and TIGIT ligand protein binding assays. SPR & BLI for CD155-specific antibody and TIGIT protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: PVR poliovirus receptor [ Homo sapiens (human) ]
• Official Symbol: PVR
• Synonyms: PVR; poliovirus receptor; PVS; CD155; HVED; Necl 5; NECL5; nectin like 5; Tage4; nectin-like 5; nectin-like protein 5; TAGE4; Necl-5; FLJ25946
• Gene ID: 5817
• mRNA Refseq: NM_001135768
• Protein Refseq: NP_001129240
• MIM: 173850
• UniProt ID: P15151