Active Recombinant Human TACSTD2 Protein, Flag&His tagged

• Cat.No.: TACSTD2-78H
• Product Overview: TROP-2 dimer protein contains a TROP-2 extracellular domain (UniProt# P09758, amino acids His27-Thr274) fused with a dimer motif followed by a tandem Flag-His tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Flag&His
• Protein Length: 27-274 aa
• Description: Human TROP-2 (trophoblast cell surface antigen 2) is a cell-surface type I transmembrane glycoprotein expressed in epithelial cells of various tissues. TROP-2 is also known as TROP2, TACSTD2, EGP-1, pancreatic carcinoma marker protein GA733-1/GA733, gastrointestinal tumor-associated antigen GA7331, GP50, M1S1, tumor-associated calcium signal transducer 2, CAA1, and TTD2. TROP-2 exists as a monomer on the cell surface but can form dimers or oligomers on cancer cells enhancing its role in cancer progression. TROP-2 contains an extracellular domain, a single transmembrane helix, and a cytoplasmic tail. The extracellular domain is comprised of three subdomains: a cysteine-rich domain, a thyroglobulin type-1 domain, and a cysteine-poor domain. TROP-2 is normally involved in the maintenance of epithelial tissue integrity. It is overexpressed in many cancers including breast cancer, non-small-cell lung cancer, thyroid cancer, gastric cancer, pancreatic cancer, and ovarian cancer. TROP-2 overexpression is involved in cancer cell growth, proliferation, invasion, migration, and survival of cancer cells, and is associated with tumor aggressiveness and poor prognosis. TROP-2 is an emerging target of cancer therapeutics.
• Molecular Mass: 72 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for TROP-2-specific antibody binding assays. Suggested Applications: ELISA for TROP-2-specific antibody binding assays. SPR & BLI for TROP-2-specific antibody binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.2μm filtered PBS, pH 7.4, no preservatives
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name 2: TACSTD2 tumor-associated calcium signal transducer 2 [Homo sapiens (human)]
• Official Symbol 2: TACSTD2
• Synonyms 2: TACSTD2; tumor-associated calcium signal transducer 2; M1S1; EGP 1; GA733 1; TROP2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal GA733; EGP1; GP50; EGP-1; GA7331; GA733-1
• Gene ID 2: 4070
• mRNA Refseq 2: NM_002353
• Protein Refseq 2: NP_002344
• MIM 2: 137290
• UniProt ID 2: P09758