Active Recombinant Human TIMP4, HIgG1 Fc-tagged

• Cat.No.: TIMP4-3244H
• Product Overview: The extracellular domain of human TIMP4(AAH10553.1)(Cys30-Pro224) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 30-224 a.a.
• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrixmetalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted,netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation andrecruitment and may play role in hormonal regulation and endometrial tissue remodeling.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production .
• Molecular Mass: 48KDa (monomer)
• AA Sequence: Cys30-Pro224
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TIMP4 TIMP metallopeptidase inhibitor 4 [ Homo sapiens ]
• Official Symbol: TIMP4
• Synonyms: TIMP4; TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4; metalloproteinase inhibitor 4; TIMP-4; tissue inhibitor of metalloproteinases 4
• Gene ID: 7079
• mRNA Refseq: NM_003256
• Protein Refseq: NP_003247
• MIM: 601915
• UniProt ID: Q99727
• Chromosome Location: 3p25
• Pathway: Matrix Metalloproteinases, organism-specific biosystem
• Function: enzyme inhibitor activity; metal ion binding; metalloendopeptidase inhibitor activity