Active Recombinant Mouse Dkk3 Protein
Cat.No. : | Dkk3-7394M |
Product Overview : | Recombinant mouse DKK-3 protein without tag was expressed in CHO cells. |
- Specification
- Gene Information
- Related Products
Description : | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Source : | CHO |
Species : | Mouse |
Form : | Lyophilized |
Bio-activity : | Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 E1 cells. The expected ED50 for this effect is 2.0–4.0 ng/mL. |
Molecular Mass : | 36.3 kDa (329aa) |
AA Sequence : | APAPTATSAPVKPGPALSYPQEEAT LNEMFREVEELMEDTQHKLRSAVEE MEAEEAAAKASSEVNLANLPPSYHN ETNTDTKVGNNTIHVHREIHKITNN QTGQMVFSETVITSVGDEEGRRSHE CIIDEDCGPSMYCQFASFQYTCQPC RGQRMLCTRDSECCGDQLCVWGHCT KMATRGSNGTICDNQRDCQPGLCCA FQRGLLFPVCTPLPVEGELCHDPAS RLLDLITWELEPDGALDRCPCASGL LCQPHSHSLVYVCKPTFVGSRDQDG EILLPREVPDEYEVGSFMEEVRQEL EDLERSLTEEMALREPAAAAAALLG GEEI |
Purity : | > 98 % by SDS-PAGE and HPLC |
Stability : | Shelf life: one year from despatch. |
Storage : | Store lyophilized at 2-8 centigrade for 6 months or at -20 centigrade long term. After reconstitution store the antibody undiluted at 2-8 centigrade for one month or (in aliquots) at -20 centigrade long term. Avoid repeated freezing and thawing. |
Reconstitution : | We recommended a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4 centigrade for one week or at –20 centigrade for future use. |
Gene Name : | Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Mus musculus (house mouse) ] |
Official Symbol : | Dkk3 |
Synonyms : | Dkk3; dickkopf WNT signaling pathway inhibitor 3; dkk-3; C87148; mDkk-3; AW061014; dickkopf-related protein 3; dickkopf homolog 3; dickkopf-3 |
Gene ID : | 50781 |
mRNA Refseq : | NM_001360257 |
Protein Refseq : | NP_001347186 |
UniProt ID : | Q9QUN9 |
Products Types
◆ Recombinant Protein | ||
Dkk3-198M | Recombinant Mouse Dkk3 Protein, His-tagged | +Inquiry |
DKK3-2667H | Recombinant Human DKK3 Protein, GST-tagged | +Inquiry |
Dkk3-2572M | Recombinant Mouse Dkk3 Protein, Myc/DDK-tagged | +Inquiry |
DKK3-001H | Active Recombinant Human DKK3 Protein, His-tagged | +Inquiry |
DKK3-2219H | Recombinant Human DKK3 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
DKK3-2672MCL | Recombinant Mouse DKK3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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