Active Recombinant Mouse Kdr Protein

Cat.No. : Kdr-7422M
Product Overview : Recombinant mouse VEGFR-2/Flk-1 (native) protein without tag was expressed in insect cells.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Source : Insect cell
Species : Mouse
Form : Lyophilized
Bio-activity : Measured by its ability to inhibit the VEGF165-induced proliferation in human umbilical vein endothelial (HUVE) cells.
Molecular Mass : ~ 105 kDa
AA Sequence : ASVGLTGDFLHPPKLSTQKDILTIL ANTTLQITCRGQRDLDWLWPNAQRD SEERVLVTECGGGDSIFCKTLTIPR VVGNDTGAYKCSYRDVDIASTVYVY VRDYRSPFIASVSDQHGIVYITENK NKTVVIPCRGSISNLNVSLCARYPE KRFVPDGNRISWDSEIGFTLPSYMI SYAGMVFCEAKINDETYQSIMYIVV VVGYRIYDVILSPPHEIELSAGEKL VLNCTARTELNVGLDFTWHSPPSKS HHKKIVNRDVKPFPGTVAKMFLSTL TIESVTKSDQGEYTCVASSGRMIKR NRTFVRVHTKPFIAFGSGMKSLVEA TVGSQVRIPVKYLSYPAPDIKWYRN GRPIESNYTMIVGDELTIMEVTERD AGNYTVILTNPISMEKQSHMVSLVV NVPPQIGEKALISPMDSYQYGTMQT LTCTVYANPPLHHIQWYWQLEEACS YRPGQTSPYACKEWRHVEDFQGGNK IEVTKNQYALIEGKNKTVSTLVIQA ANVSALYKCEAINKAGRGERVISFH VIRGPEITVQPAAQPTEQESVSLLC TADRNTFENLTWYKLGSQATSVHMG ESLTPVCKNLDALWKLNGTMFSNST NDILIVAFQNASLQDQGDYVCSAQD KKTKKRHCLVKQLIILGMEASLGDR IAMP
Endotoxin : < 0.1 ng/μg of esKDR
Purity : > 95 % by SDS-PAGE and Silver staining
Stability : Shelf life: one year from despatch.
Storage : Store lyophilized at 2-8 centigrade for 6 months or at -20 centigrade long term.
After reconstitution store the antibody undiluted at 2-8 centigrade for one month or (in aliquots) at -20 centigrade long term.
Avoid repeated freezing and thawing.
Storage Buffer : 25 mM MES, 100 mM NaCl, pH 5.5
Reconstitution : Restore in water or PBS to a concentration of not lower than 100 μg/mL.
Gene Name : Kdr kinase insert domain protein receptor [ Mus musculus (house mouse) ]
Official Symbol : Kdr
Synonyms : Kdr; kinase insert domain protein receptor; Flk; orv; Flk-; Flk1; Ly73; VEGF; Flk-1; Krd-1; VEGFR; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07; vascular endothelial growth factor receptor 2; VEGF receptor-2; fetal liver kinase 1; kinase NYK; protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor-3; EC 2.7.10.1
Gene ID : 16542
mRNA Refseq : NM_010612
Protein Refseq : NP_034742
UniProt ID : P35918

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All Kdr Products

Required fields are marked with *

My Review for All Kdr Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /
  • Service lnquiry:

Stay Updated on the Latest Bioscience Trends