Active Recombinant Mouse Tacstd2 Homodimer Protein, Flag&His tagged

• Cat.No.: Tacstd2-64M
• Product Overview: TROP-2 protein dimer contains a TROP-2 extracellular domain (UniProt# Q8BGV3) fused with a proprietary cis-dimer motif followed by a tandem FLAG-His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: Flag&His
• Protein Length: 25-270 aa
• Description: TROP-2 (trophoblast cell surface antigen 2) is a cell-surface type I transmembrane glycoprotein expressed in epithelial cells of various tissues. TROP-2 is also known as TROP2, TACSTD2, EGP-1, pancreatic carcinoma marker protein GA733–1/GA733, gastrointestinal tumor-associated antigen GA7331, GP50, M1S1, tumor-associated calcium signal transducer 2, CAA1, and TTD2. TROP-2 exists as a monomer on the cell surface but can form dimers or oligomers on cancer cells, enhancing its role in cancer progression. TROP-2 contains an extracellular domain, a single transmembrane helix, and a cytoplasmic tail. The extracellular domain is comprised of three subdomains: a cysteine-rich domain, a thyroglobulin type-1 domain, and a cysteine-poor domain. TROP-2 is normally involved in the maintenance of epithelial tissue integrity. It is overexpressed in many human cancers including breast cancer, non-small-cell lung cancer, thyroid cancer, gastric cancer, pancreatic cancer, and ovarian cancer. TROP-2 overexpression is involved in cancer cell growth, proliferation, invasion, migration, and survival of cancer cells, and is associated with tumor aggressiveness and poor prognosis. TROP-2 is an emerging target of cancer therapeutics. Mouse TROP-2 shares 80–85% amino acid identity with human TROP-2. The functional domains are highly conserved, suggesting similar biological roles.
• Molecular Mass: 74 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for TROP-2-specific antibody binding assays. Suggested Applications: SPR & BLI for TROP-2-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: Tacstd2 tumor-associated calcium signal transducer 2 [ Mus musculus (house mouse) ]
• Official Symbol: Tacstd2
• Synonyms: TACSTD2; tumor-associated calcium signal transducer 2; lymphocyte antigen 97; cell surface glycoprotein Trop-2; tunor-associated calcium signal transducer 2; Ly97; EGP-1; TROP2; C80403; GA733-1; MGC141612; MGC141613
• Gene ID: 56753
• mRNA Refseq: NM_020047
• Protein Refseq: NP_064431
• UniProt ID: Q8BGV3