Active Recombinant SARS Spike Protein S1 Domain, Fc-tagged
| Cat.No. : | Spike-43V |
| Product Overview : | Recombinant SARS Spike Protein S1 Domain (19-713aa) was fused to Fc-tag and expressed using recombinant baculoviruses and purified from the infected cell supernatant by protein A affinity chromatography. |
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- Gene Information
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| Description : | Spike protein S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. |
| Source : | Baculoviruses |
| Species : | SARS-CoV |
| Tag : | Human IgG1 Fc |
| Form : | Freeze-dried in PBS without preservative. |
| Bio-activity : | Purified SCoV S1-Fc is active in binding the Vero E6 cell surface and recombinant ACE2. |
| Protein length : | 19-713aa |
| Purity : | > 90% |
| Storage : | Desiccated at +2 to +8 centigrade. Reconstituted product should be stored in aliquots at –20 centigrade. |
| Reconstitution : | Reconstitute with sterile double distilled water. Recommended final concentration 1 mg/ml. |
| Gene Name : | S |
| Official Symbol : | S |
| Synonyms : | E2 |
| Gene ID : | 1489668 |
| Protein Refseq : | NP_828851.1 |
| UniProt ID : | P59594 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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