"WHSC2" Related Products

Recombinant Human Wolf-Hirschhorn Syndrome Candidate 2, T7-tagged

Cat. No. : WHSC2-3015H
Product Overview : Recombinant Human WHSC2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 57349 Da(525 aa).
Description : Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. WHSC2 encodes the NELF-A subunit of the NELF complex.
Sequences of amino acids : 1-525 aa
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
Purity : 90%
Gene Name : WHSC2 Wolf-Hirschhorn syndrome candidate 2 [ Homo sapiens ]
Synonyms : Wolf-Hirschhorn syndrome candidate 2;NELFA; NELF-A; FLJ10442; FLJ25112; P/OKcl.15; WHSC2; negative elongation factor A; OTTHUMP00000211580
Gene ID : 7469
mRNA Refseq : NM_005663
Protein Refseq : NP_005654
MIM : 606026
UniProt ID : Q9H3P2
Chromosome Location : 4p16.3
Pathway : Gene Expression; HIV Infection; Transcription

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