Recombinant Human BAG2, His-tagged

• Cat.No.: BAG2-3406H
• Product Overview: Recombinant human BAG2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: BCL2-associated athanogene 2, also known as BAG2, is a member of the Bag family of proteins. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain. BAG2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.1M NaCl.
• Molecular Weight: 25.9 kDa (231aa) confirmed by MALDI-TOF.
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLD QLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMRQISDGEREEL NLTA NRLM GR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACS SEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEH SKG AG SK TLQQNAESRF N.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Protein processing in endoplasmic reticulum

Gene Information

• Gene Name: BAG2 BCL2-associated athanogene 2 [ Homo sapiens ]
• Synonyms: BCL2-associated athanogene 2; BAG-2; KIAA0576; MGC149462; dJ417I1.2; BAG2; BAG family molecular chaperone regulator 2; bcl-2-associated athanogene 2; BAG-family molecular chaperone regulator-2; dJ417I1.2 (BAG-family molecular chaperone regulator 2); Bcl-2-associated athanogene 2
• Gene ID: 9532
• mRNA Refseq: NM_004282
• Protein Refseq: NP_004273
• MIM: 603882
• UniProt ID: O95816
• Chromosome Location: 6p12.1-p11.2
• Function: protein binding