"CDC25A" Related Products

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Recombinant Human CDC25A protein, His-tagged

Cat.No.: CDC25A-3440H
Product Overview: Recombinant Human CDC25A(1-524aa) fused with His tag at N-terminal was expressed in E. coli.
Description: M-phase inducer phosphatase 1, also known as CDC25A, is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 20% glycerol, 0.2M NaCl, 1mM EDTA
Molecular Mass: 63.2 kDa (560aa)
AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLGSDYEQPLE VKNNSNLQRM GSSESTDSGF CLDSPGPLDS KENLENPMRR IHSLPQKLLG CSPALKRSHS DSLDHDIFQL IDPDENKENE MELG PEPPHRRRLL FACSPPPASQ PVVKALFGAS AAGGLSPVTN LTVTMDQLQGAFEFKKPVRP VSRGCLHSHG LQEGKDLFTQ RQNSAPARML SSNERDSSEP GNFIPLFTPQ SPVTATLSDE DDGFVDLLDG ENLKNEEETPSCMASLWTAP LVMRTTNLDN RCKLFDSPSL CSSSTRSVLK RPERSQEESP PGSTKRRKSM SGASPKESTN PEKAHETLHQ SLSLASSPKGTIENILDNDP RDLIGDFSKG YLFHTVAGKH QDLKYISPEI MASVLNGKFA NLIKEFVIID CRYPYEYEGG HIKGAVNLHM EEEVEDFLLKKPIVPTDGKR VIVVFHCEFS SERGPRMCRY VRERDRLGNE YPKLHYPELY VLKGGYKEFF MKCQSYCEPP SYRPMHHEDF KEDLKKFRTKSRTWAGEKSK REMYSRLKKL
Purity: >80% by SDS - PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.25 mg/ml (determined by Bradford assay)
Gene Name: CDC25A cell division cycle 25 homolog A (S. pombe) [ Homo sapiens ]
Official Symbol: CDC25A
Synonyms: CDC25A; cell division cycle 25 homolog A (S. pombe); cell division cycle 25 homolog A (S. cerevisiae) , cell division cycle 25A; M-phase inducer phosphatase 1; CDC25A2-CAG isoform; cell division cycle 25A; dual specificity phosphatase CDC25A; CDC25A2;
Gene ID: 993
mRNA Refseq: NM_001789
Protein Refseq: NP_001780
MIM: 116947
UniProt ID: P30304
Chromosome Location: 3p21
Pathway: Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function: hydrolase activity; protein binding; protein kinase binding; protein tyrosine phosphatase activity;

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