Native Human Cathepsin L1

• Cat.No.: CTSL1-1859H
• Product Overview: Native Human CTSL1 was expressed in Human Liver.

Specification

• Cat. No.: CTSL1-1859H
• Description: The mostpowerful of the lysosomal proteases. It has a higher specific activity thancathepsin B and H in the degradation of a variety of physiological proteinsubstrates. The level of CTSL1 is a strongpredictor of relapse and survival following treatment of a primary breasttumor.
• Form: Frozenliquid in a buffer of 0.02 M Malonate + 0.4M NaCl + 1 mM EDTA, pH 5.5.
• Source: Human Liver
• Molecular Weight: 25-29 kDa
• Purity: > 95% by SDS-PAGE
• Specific Activity: ≥ 1 unitper mg protein. One unit is defined as the amount of enzyme that hydrolyzes onemicromole of Z-Phe-Arg-AFC per minute at 25°C using 400 mM Na Acetate, pH 5.5with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij.
• Concentration: 1.0 mg/ml
• Storage: Product is stable at -80°Cfor 3 years.
• OfficialSymbol: CTSL1
• Pathways: Lysosome; Antigen processing andpresentation; Phagosome; Rheumatoid arthritis

Gene Information

• Gene Name: CTSL1cathepsin L1 [ Homo sapiens ]
• Synonyms: CTSL1; cathepsin L1; MEP; CATL;CTSL; FLJ31037; EC 3.4.22.15; OTTHUMP00000021601; OTTHUMP00000021602;OTTHUMP00000063566; Major excreted protein; major excreted protein; CathepsinL1; Cathepsin L1 heavy chain; Cathepsin L1 light chain
• Gene ID: 1514
• mRNA Refseq: NM_001912
• Protein Refseq: NP_001903
• MIM: 116880
• UniProt ID: P07711
• Chromosome Location: 9q21.33
• Function: cysteine-typeendopeptidase activity; peptidase activity; histone binding; proteinbinding