Native Human Cathepsin L1

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Native Human Cathepsin L1

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Cat. No. : CTSL1-1859H
Product Overview : Native Human CTSL1 was expressed in Human Liver.
Description : The mostpowerful of the lysosomal proteases. It has a higher specific activity thancathepsin B and H in the degradation of a variety of physiological proteinsubstrates. The level of CTSL1 is a strongpredictor of relapse and survival following treatment of a primary breasttumor.
Form : Frozenliquid in a buffer of 0.02 M Malonate + 0.4M NaCl + 1 mM EDTA, pH 5.5.
Source : Human Liver
Molecular Weight : 25-29 kDa
Purity : > 95% by SDS-PAGE
Specific Activity : ≥ 1 unitper mg protein. One unit is defined as the amount of enzyme that hydrolyzes onemicromole of Z-Phe-Arg-AFC per minute at 25°C using 400 mM Na Acetate, pH 5.5with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij.
Concentration : 1.0 mg/ml
Storage : Product is stable at -80°Cfor 3 years.
OfficialSymbol : CTSL1
Pathways : Lysosome; Antigen processing andpresentation; Phagosome; Rheumatoid arthritis
PDBrendering based on 1cjl. :

Gene Name : CTSL1cathepsin L1 [ Homo sapiens ]
Synonyms : CTSL1; cathepsin L1; MEP; CATL;CTSL; FLJ31037; EC 3.4.22.15; OTTHUMP00000021601; OTTHUMP00000021602;OTTHUMP00000063566; Major excreted protein; major excreted protein; CathepsinL1; Cathepsin L1 heavy chain; Cathepsin L1 light chain
Gene ID : 1514
mRNA Refseq : NM_001912
Protein Refseq : NP_001903
MIM : 116880
UniProt ID : P07711
Chromosome Location : 9q21.33
Function : cysteine-typeendopeptidase activity; peptidase activity; histone binding; proteinbinding

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