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Recombinant Human Activating Transcription Factor 1, His-tagged

Cat.No. : ATF1-1374H
Product Overview : Recombinanthuman ATF1protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.
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  • Gene Information
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Cat. No. : ATF1-1374H
Description : ATF1 is a cyclic-AMPdependent transcription factor. ATF1 is expressed in a wide variety of celltypes and is capable of dimerizing with CREB. MSK1 and MSK2 protein kinasesare required for the stress-induced phosphorylation of transcription factorsCREB and ATF1 in primary embryonic fibroblasts. Epidermal growth factorinduction of c-jun expression requires ATF1 and MEF2 sites in the c-junpromoter.
Form : Liquid. In 20 mMTris-HCl buffer (pH 8.0) containing 5 mM DTT, 50% glycerol, 0.2M NaCl, 2 mM EDTA.
Molecular Weight : 31.8 kDa(295 aa), confirmed by MALDI-TOF.
Purity : > 90%by SDS-PAGE
Concentration : 0.25mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MGSHMEDSHK STTSETAPQP GSAVQGAHIS HIAQQVSSLS ESEESQDSSDSIGSSQKAHG ILARRPSYRK ILKDLSSEDT RGRKGDGENS GVSAAVTSMSVPTPIYQTSS GQYIAIAPNG ALQLASPGTD GVQGLQTLTM TNSGSTQQGT TILQYAQTSD GQQILVPSNQVVVQTASGDM QTYQIRTTPS ATSLPQTVVM TSPVTLTSQT TKTDDPQLKR EIRLMKNREA ARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLY SNKSV
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : ActivatedTLR4 signalling; CREB phosphorylation; EGFR1 Signaling Pathway; ErbB1downstream signaling; HTLV-I infection; IL-3 Signaling Pathway; ImmuneSystem; Innate Immunity Signaling; MAP kinase activation in TLR cascade;MyD88 cascade initiated on plasma membrane; Myometrial Relaxation andContraction Pathways; NGF signalling via TRKA from the plasma membrane;Serotonin Receptor 4/6/7 and NR3C Signaling; Signalling by NGF; TRAF6Mediated Induction of proinflammatory cytokines; Toll Like Receptor 10(TLR10) Cascade; Toll Like Receptor 2 Cascade
Gene Name : ATF1 activating transcriptionfactor 1 [ Homo sapiens ]
Official Symbol : ATF1
Synonyms : ATF1; activatingtranscription factor 1; TREB36; EWS-ATF1;FUS/ATF-1; cyclic AMP-dependent transcription factor ATF-1; cAMP-dependenttranscription factor ATF-1
Gene ID : 466
mRNA Refseq : NM_005171
Protein Refseq : NP_005162
MIM : 123803
UniProt ID : P18846
Chromosome Location : 12q13
Function : proteincomplex binding ; protein heterodimerization activity ; sequence-specific DNAbinding ; sequence-specific DNA binding transcription factor activity ;sequence-specific distal enhancer binding RNA polymerase II transcriptionfactor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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