Recombinant Human Casein Kinase 2, Alpha 1 Polypeptide, His-tagged

• Cat.No.: CSNK2A1-1208H
• Product Overview: Recombinant humanfull length CSNK2A1 with His tag. No special measures were taken to activatethis kinase.

Specification

• Cat. No.: CSNK2A1-1208H
• Description: Casein kinase IIsubunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene.Casein kinase II is a serine/threonine protein kinase that phosphorylatesacidic proteins such as casein. The kinase exists as a tetramer and iscomposed of an alpha, an alpha-prime, and two beta subunits. The alphasubunits contain the catalytic activity while the beta subunits undergoautophosphorylation. The protein encoded by this gene represents the alphasubunit. While this gene is found on chromosome 20, a related transcribedpseudogene is found on chromosome 11. Three transcript variants encoding twodifferent proteins have been found for this gene.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 100 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 47.9 kDa
• Concentration: 0.37 mg/ml
• Purity: ≥ 90% as determined by SDS-PAGE analysis.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: CSNK2A1

Gene Information

• Gene Name: CSNK2A1 casein kinase 2, alpha 1polypeptide [ Homo sapiens ]
• Synonyms: CSNK2A1; caseinkinase 2, alpha 1 polypeptide; CKII; CK2A1; casein kinase II subunit alpha;CK II alpha; OTTHUMP00000029925; OTTHUMP00000029926; protein kinase CK2; CK2catalytic subunit alpha; casein kinase II alpha 1 subunit; EC 2.7.11
• Gene ID: 1457
• mRNA Refseq: NM_001895
• Protein Refseq: NP_001886
• MIM: 115440
• UniProt ID: P68400
• Chromosome Location: 20p13
• Pathway: Adherens junction;Alpha-synuclein signaling; Axon guidance; BCR signaling pathway;Developmental Biology; Herpes simplex infection; L1CAM interactions; Measles;PDGFR-alpha signaling pathway; Presenilin action in Notch and Wnt signaling;Ribosome biogenesis in eukaryotes; Signal transduction by L1; Tight junction;Wnt Signaling Pathway NetPath; Wnt signaling pathway
• Function: ATP binding;beta-catenin binding; nucleotide binding; protein N-terminus binding; proteinbinding; protein phosphatase regulator activity; protein serine/threoninekinase activity; transferase activity, transferring phosphorus-containinggroups