Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1
Cat.No. : | LRPAP1-1251H |
Product Overview : | Recombinant human LRPAP1 is expressed in E. coli. |
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- Gene Information
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Cat. No. : | LRPAP1-1251H |
Description : | LRPAP1is a 39 kDa receptor-associated protein capable of universally inhibitingligand interaction with members of the LDL Receptor family that mediateendocytosis and signal transduction of many extracellular ligands whichparticipate in lipoprotein metabolism, protease regulation, embryonicdevelopment, and the pathogenesis of disease. It also binds tightly to gp330,an endocytic receptor that resembles LRP and is abundantly expressed in thekidney, and to the Very Low Density Lipoprotein (VLDL) Receptor. LRPAP1 promotesthe proper folding of these receptors, a function that is likely independentfrom its ability to inhibit ligand binding. Some evidence suggests LRPAP1 mayplay a role in regulating the expression of LRP, possibly by stabilizing thereceptor during biosynthesis or transport along the secretory pathway, andcould be a short-acting modulator of LRP activity. |
Source : | E. coli |
Species : | Human |
Form : | Frozen Liquid in 0.1M Tris-HCl + 0.1 M NaCl pH 7.4. |
Concentration : | 2.5 mg/mL |
Molecular Weight : | 39 kDa |
Applications : | Suitableto block receptor function in uptake assays. |
Storage : | Store at-70°C. 3 years. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | LRPAP1 |
Gene Name : | LRPAP1low density lipoprotein receptor-related protein associated protein 1 [ Homosapiens ] |
Synonyms : | LRPAP1; lowdensity lipoprotein receptor-related protein associated protein 1; RAP;MRAP; A2RAP; HBP44; A2MRAP; MGC138272; alpha-2-macroglobulinreceptor-associated protein; alpha-2-MRAP; OTTHUMP00000115346; OTTHUMP00000217120;alpha-2-macroglobulin receptor-associated protein 1; low-densitylipoprotein receptor-related protein associated protein 1; low-densitylipoprotein-related protein-associated protein 1 (alpha-2-macroglobulinreceptor-associated protein 1); lipoprotein receptor associated protein |
Gene ID : | 4043 |
mRNA Refseq : | NM_002337 |
Protein Refseq : | NP_0023328 |
MIM : | 104225 |
UniProt ID : | P30533 |
Chromosome Location : | 4p16.3 |
Pathway : | Lissencephaly gene(LIS1) in neuronal migration and development; Reelin signaling pathway; Signalingevents mediated by the Hedgehog family |
Function : | heparinbinding; lipase binding; unfolded protein binding; low-density lipoproteinparticle receptor binding; asialoglycoprotein receptor activity; receptorantagonist activity; very-low-density lipoprotein particle receptor binding |
Products Types
◆ Recombinant Protein | ||
LRPAP1-2017H | Recombinant Human LRPAP1 Protein, His-tagged | +Inquiry |
LRPAP1-848H | Recombinant Human LRPAP1 Protein, MYC/DDK-tagged | +Inquiry |
Lrpap1-1340M | Recombinant Mouse Lrpap1 Protein, MYC/DDK-tagged | +Inquiry |
LRPAP1-3112R | Recombinant Rat LRPAP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LRPAP1-4687H | Recombinant Human LRPAP1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
LRPAP1-2574HCL | Recombinant Human LRPAP1 cell lysate | +Inquiry |
LRPAP1-2168MCL | Recombinant Mouse LRPAP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLRPAP1 may be a potential therapeutic target in diseases where its interactions with LRP1 play a crucial role, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.
LRPAP1 has been implicated in immune system regulation, and its interactions with LRP1 may impact immune responses, suggesting potential applications in immunotherapy.
Genetic variations or mutations in the LRPAP1 gene have been investigated in the context of certain diseases, and understanding these variations may provide insights into disease susceptibility and progression.
LRPAP1 plays a role in lipoprotein metabolism by influencing the function of LRP1, a receptor involved in the clearance of lipoproteins from the circulation, thus impacting cardiovascular health.
Understanding the role of LRPAP1 in various diseases may contribute to personalized medicine by identifying individuals who could benefit from targeted therapies based on their specific genetic or molecular profiles.
Customer Reviews (3)
Write a reviewThis technical support is invaluable, especially for researchers who may be new to working with LRPAP1 protein or if they encounter specific difficulties while conducting their experiments.
They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.
the manufacturer's technical expertise can be advantageous to researchers.
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