"LRPAP1" Related Products

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Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1

Cat. No.: LRPAP1-1251H
Product Overview: Recombinant human LRPAP1 is expressed in E. coli.
Description: LRPAP1is a 39 kDa receptor-associated protein capable of universally inhibitingligand interaction with members of the LDL Receptor family that mediateendocytosis and signal transduction of many extracellular ligands whichparticipate in lipoprotein metabolism, protease regulation, embryonicdevelopment, and the pathogenesis of disease. It also binds tightly to gp330,an endocytic receptor that resembles LRP and is abundantly expressed in thekidney, and to the Very Low Density Lipoprotein (VLDL) Receptor. LRPAP1 promotesthe proper folding of these receptors, a function that is likely independentfrom its ability to inhibit ligand binding. Some evidence suggests LRPAP1 mayplay a role in regulating the expression of LRP, possibly by stabilizing thereceptor during biosynthesis or transport along the secretory pathway, andcould be a short-acting modulator of LRP activity.
Source: E. coli
Species: Human
Form: Frozen Liquid in 0.1M Tris-HCl + 0.1 M NaCl pH 7.4.
Concentration: 2.5 mg/mL
Molecular Weight: 39 kDa
Applications: Suitableto block receptor function in uptake assays.
Storage: Store at-70°C. 3 years. Avoid repeated freeze-thaw cycles.
OfficialSymbol: LRPAP1
Gene Name: LRPAP1low density lipoprotein receptor-related protein associated protein 1 [ Homosapiens ]
Synonyms: LRPAP1; lowdensity lipoprotein receptor-related protein associated protein 1; RAP;MRAP; A2RAP; HBP44; A2MRAP; MGC138272; alpha-2-macroglobulinreceptor-associated protein; alpha-2-MRAP; OTTHUMP00000115346; OTTHUMP00000217120;alpha-2-macroglobulin receptor-associated protein 1; low-densitylipoprotein receptor-related protein associated protein 1; low-densitylipoprotein-related protein-associated protein 1 (alpha-2-macroglobulinreceptor-associated protein 1); lipoprotein receptor associated protein
Gene ID: 4043
mRNA Refseq: NM_002337
Protein Refseq: NP_0023328
MIM: 104225
UniProt ID: P30533
Chromosome Location: 4p16.3
Pathway: Lissencephaly gene(LIS1) in neuronal migration and development; Reelin signaling pathway; Signalingevents mediated by the Hedgehog family
Function: heparinbinding; lipase binding; unfolded protein binding; low-density lipoproteinparticle receptor binding; asialoglycoprotein receptor activity; receptorantagonist activity; very-low-density lipoprotein particle receptor binding

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