Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged


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Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged

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Cat. No. : LYN-1254H
Product Overview : Recombinanthuman full length LYN with C-terminal His tag. LYN is a SRC family kinaseexpressed predominantly in hematopoietic cells.
Description : LYN is a member ofthe Src family of protein tyrosine kinases, which is mainly expressed inhematopoietic cells, in neural tissues liver, and adipose tissue. In varioushematopoietic cells, LYN has emerged as a key enzyme involved inthe regulation of cell activation. In these cells, a small amount of LYN isassociated with cell surface receptor proteins, including the B cell antigenreceptor (BCR), CD40, or CD19.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 0.05 mM EDTA + 1 mM DTT + 100 mM NaCl + 0.05% NP-40 +50% glycerol.
Molecular Weight : 57.4 kDa
Purity : > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
Specific Activity : 772 nmoleof phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mgof totalprotein at 30°C.Activity determined at a final protein concentration of 2 μg/ml.
Concentration : 0.27mg/ml
Storage : Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : LYN
nullValue_other :
Functionubiquitin proteinligase binding; receptor signaling protein tyrosine kinase activity; proteintyrosine kinase activity; protein binding; platelet-derived growth factor receptorbinding; phosphoprotein binding; nucleotide binding; non-membrane spanningprotein tyrosine kinase activity; ion channel binding; integrin binding; glycosphingolipidbinding; SH3 domain binding; ATP binding
Gene Name : LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens]
Synonyms : LYN; v-yes-1Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Tyrosine-protein kinase Lyn; EC2.7.10.2; Yamaguchi sarcoma viral related oncogene homolog; EC 2.7.10; OTTHUMP00000226393;OTTHUMP00000226394
Gene ID : 4067
mRNA Refseq : NM_001111097
Protein Refseq : NP_001104567
MIM : 165120
UniProt ID : P07948
Chromosome Location : 8q13
Pathway : Adaptive ImmuneSystem; Alpha-synuclein signaling; B Cell Receptor Signaling Pathway; BCRsignaling pathway; CD28 co-stimulation; CTLA4 inhibitory signaling; CXCR4-mediatedsignaling events; Chemokine signaling pathway; Class I PI3K signaling events;Costimulation by the CD28 family; Cytokine Signaling in Immune system; EPHAforward signaling; EPO signaling pathway; Ephrin B reverse signaling; Epithelialcell signaling in Helicobacter pylori infection; Fc epsilon RI signalingpathway; Fc gamma R-mediated phagocytosis; GPVI-mediated activation cascade; Glypican1 network
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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