Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged

• Cat.No.: LYN-1254H
• Product Overview: Recombinanthuman full length LYN with C-terminal His tag. LYN is a SRC family kinaseexpressed predominantly in hematopoietic cells.

Specification

• Cat. No.: LYN-1254H
• Description: LYN is a member ofthe Src family of protein tyrosine kinases, which is mainly expressed inhematopoietic cells, in neural tissues liver, and adipose tissue. In varioushematopoietic cells, LYN has emerged as a key enzyme involved inthe regulation of cell activation. In these cells, a small amount of LYN isassociated with cell surface receptor proteins, including the B cell antigenreceptor (BCR), CD40, or CD19.
• Source: Insect cells
• Species: Human
• Form: Liquid in50 mM Tris, pH 7.5 + 0.05 mM EDTA + 1 mM DTT + 100 mM NaCl + 0.05% NP-40 +50% glycerol.
• Molecular Weight: 57.4 kDa
• Purity: > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
• Specific Activity: 772 nmoleof phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mgof totalprotein at 30°C.Activity determined at a final protein concentration of 2 μg/ml.
• Concentration: 0.27mg/ml
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: LYN
• Function: ubiquitin proteinligase binding; receptor signaling protein tyrosine kinase activity; proteintyrosine kinase activity; protein binding; platelet-derived growth factor receptorbinding; phosphoprotein binding; nucleotide binding; non-membrane spanningprotein tyrosine kinase activity; ion channel binding; integrin binding; glycosphingolipidbinding; SH3 domain binding; ATP binding

Gene Information

• Gene Name: LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens]
• Synonyms: LYN; v-yes-1Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Tyrosine-protein kinase Lyn; EC2.7.10.2; Yamaguchi sarcoma viral related oncogene homolog; EC 2.7.10; OTTHUMP00000226393;OTTHUMP00000226394
• Gene ID: 4067
• mRNA Refseq: NM_001111097
• Protein Refseq: NP_001104567
• MIM: 165120
• UniProt ID: P07948
• Chromosome Location: 8q13
• Pathway: Adaptive ImmuneSystem; Alpha-synuclein signaling; B Cell Receptor Signaling Pathway; BCRsignaling pathway; CD28 co-stimulation; CTLA4 inhibitory signaling; CXCR4-mediatedsignaling events; Chemokine signaling pathway; Class I PI3K signaling events;Costimulation by the CD28 family; Cytokine Signaling in Immune system; EPHAforward signaling; EPO signaling pathway; Ephrin B reverse signaling; Epithelialcell signaling in Helicobacter pylori infection; Fc epsilon RI signalingpathway; Fc gamma R-mediated phagocytosis; GPVI-mediated activation cascade; Glypican1 network