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Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged

Cat. No. : LYN-1254H
Product Overview : Recombinanthuman full length LYN with C-terminal His tag. LYN is a SRC family kinaseexpressed predominantly in hematopoietic cells.
Description : LYN is a member ofthe Src family of protein tyrosine kinases, which is mainly expressed inhematopoietic cells, in neural tissues liver, and adipose tissue. In varioushematopoietic cells, LYN has emerged as a key enzyme involved inthe regulation of cell activation. In these cells, a small amount of LYN isassociated with cell surface receptor proteins, including the B cell antigenreceptor (BCR), CD40, or CD19.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 0.05 mM EDTA + 1 mM DTT + 100 mM NaCl + 0.05% NP-40 +50% glycerol.
Molecular Weight : 57.4 kDa
Purity : > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
Specific Activity : 772 nmoleof phosphate transferred to poly [Glu, Tyr] 4:1 substrate per minute per mgof totalprotein at 30°C.Activity determined at a final protein concentration of 2 μg/ml.
Concentration : 0.27mg/ml
Storage : Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : LYN
nullValue_other :
Functionubiquitin proteinligase binding; receptor signaling protein tyrosine kinase activity; proteintyrosine kinase activity; protein binding; platelet-derived growth factor receptorbinding; phosphoprotein binding; nucleotide binding; non-membrane spanningprotein tyrosine kinase activity; ion channel binding; integrin binding; glycosphingolipidbinding; SH3 domain binding; ATP binding
PDB rendering basedon 1wa7. :

Gene Name : LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog [ Homo sapiens]
Synonyms : LYN; v-yes-1Yamaguchi sarcoma viral related oncogene homolog; JTK8; FLJ26625; Tyrosine-protein kinase Lyn; EC2.7.10.2; Yamaguchi sarcoma viral related oncogene homolog; EC 2.7.10; OTTHUMP00000226393;OTTHUMP00000226394
Gene ID : 4067
mRNA Refseq : NM_001111097
Protein Refseq : NP_001104567
MIM : 165120
UniProt ID : P07948
Chromosome Location : 8q13
Pathway : Adaptive ImmuneSystem; Alpha-synuclein signaling; B Cell Receptor Signaling Pathway; BCRsignaling pathway; CD28 co-stimulation; CTLA4 inhibitory signaling; CXCR4-mediatedsignaling events; Chemokine signaling pathway; Class I PI3K signaling events;Costimulation by the CD28 family; Cytokine Signaling in Immune system; EPHAforward signaling; EPO signaling pathway; Ephrin B reverse signaling; Epithelialcell signaling in Helicobacter pylori infection; Fc epsilon RI signalingpathway; Fc gamma R-mediated phagocytosis; GPVI-mediated activation cascade; Glypican1 network

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