Recombinant Human Osteoprotegerin Ligand
Cat.No. : | TNFSF11-P1002H |
Product Overview : | Recombinanthuman OPGL fused with Fc fragment of Human IgG or 6His was produced in CHOcells. |
- Specification
- Gene Information
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Cat. No. : | TNFSF11-P1002H |
Description : | Thetumour-necrosis-factor-family molecule osteoprotegerin ligand has beenidentified as a potential osteoclast differentiation factor and regulator ofinteractions between T cells and dendritic cells in vitro. OPGL is a newregulator of lymph-node organogenesis and lymphocyte development and is anessential osteoclast differentiation factor in vivo. Osteoblasts/stromalcells express OPGL /TNF-related activation-induced cytokine /receptoractivator of NF-kB ligand (RANKL)" as a membrane associated factor.Osteoclast precursors which possess RANK, a TNF receptor family member,recognize OPGL/TRANCE/RANKL through cell-to-cell interaction withosteoblasts/stromal cells, and differentiate into osteoclasts in the presenceof macrophage colony-stimulating factor. |
ProteinConstruction : | Recombinanthuman OPGL is combined the Sequence of extracellular region of OPGL and Fcfragment of Human IgG or 6His. |
Source : | ChineseHamster Ovary (CHO cell) |
Purity : | >95%as determined by SDS-PAGE and HPLC |
Endotoxin : | <1.0EU per 10 mg protein as determined by the LAL method |
Stability : | Samplesare stable for up to six months from date of receipt at -20℃ and are stable fortwo months at 4℃. |
Molecular Mass : | Recombinant humanOPGL comprises 410 and 184 amino acids of OPGL-Fc and OPGL-6His,respectively. It is about 80kDa and 33 kDa of OPGL-Fc and OPGL-6His, underreducing conditions, respectively. |
Predicted N terminal : | IRAEKAMVDG |
Formulation : | Normally20-50mM NaAC-HAC and 100-150 mM NaCl are added, pH 5.0-6.0. |
Storage : | Store itunder sterile conditions at -70℃upon receiving. Recommend to pack the protein intosmaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | TNFSF11 tumor necrosis factor (ligand) superfamily, member11 [ Homo sapiens ] |
Official Symbol : | TNFSF11 |
Synonyms : | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11;ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; tumor necrosis factorligand superfamily, member 11; OTTHUMP00000178585; osteoprotegerin ligand;osteoclast differentiation factor; TNF-related activation-induced cytokine;receptor activator of nuclear factor kappa B ligand; Tumor necrosis factorligand superfamily member 11, membrane form; Tumor necrosis factor ligandsuperfamily member 11, soluble form; CD254 antigen; Osteoprotegerin ligand |
Gene ID : | 8600 |
mRNA Refseq : | NM_003701 |
Protein Refseq : | NP_003692 |
MIM : | 602642 |
UniProt ID : | O14788 |
Chromosome Location : | 13q14 |
Pathway : | Cytokine-cytokine receptor interaction; IL6-mediated signaling events; Osteoblast Signaling |
Function : | cytokineactivity; protein binding; receptor activity; tumor necrosis factor receptorbinding |
Products Types
◆ Recombinant Protein | ||
TNFSF11-302H | Active Recombinant Human TNFSF11 Protein (Glu143-Asp317), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TNFSF11-5859R | Recombinant Rat TNFSF11 Protein, His (Fc)-Avi-tagged | +Inquiry |
Tnfsf11-85M | Active Recombinant Mouse Tnfsf11 Protein (Pro143-Asp316), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TNFSF11-683M | Recombinant Mouse TNFSF11 Protein | +Inquiry |
TNFSF11-2025R | Recombinant Rat TNFSF11 Protein | +Inquiry |
◆ Lysates | ||
TNFSF11-998HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-1093HCL | Recombinant Human TNFSF11 cell lysate | +Inquiry |
TNFSF11-001CCL | Recombinant Cynomolgus TNFSF11 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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