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Active Recombinant Human MAM Domain Containing Glycosylphosphatidylinositol Anchor 2, His-tagged

Cat.No. : MDGA2-5687H
Product Overview : Recombinant Human MDGA2protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag. Gln21-Asp931.
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  • Gene Information
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Cat. No. : MDGA2-5687H
Description : MDGA2 is a 130 kDamember of the Ig superfamily of proteins. Human MDGA2 is synthesized as a 956amino acid (aa) precursor that contains a 25 aa signal sequence, a 906 aamature chain, and a 25 aa propeptide. The mature chain consists of sixIg-like domains, followed by a MAM domain (aa 746-921) and a GPI anchor. Inaddition, there are eight potential sites for N-linked glycosylation. Maturehuman MDGA2 shares 98% aa sequence identity with mature mouse and rat MDGA2.MDGA2 is structurally similar to other IgCAMS, such as the L1 family andaxonin 1, which have roles in cell adhesion, migration, and processoutgrowth.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Gln21 predicted
Molecular Weight : 103.2kDa
Activity : Measuredby its ability to enhance neurite outgrowth of E18 rat embryonic corticalneurons. Able to significantly enhance neurite outgrowth when immobilized at7.5-30 μg on a nitrocellulose-coated microplate.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 105-125kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 200μg/mL in sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Publication :
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome. (2015)
Gene Name : MDGA2 MAM domain containingglycosylphosphatidylinositol anchor 2 [ Homo sapiens ]
Official Symbol : MDGA2
Synonyms : MDGA2; MAM domaincontaining glycosylphosphatidylinositol anchor 2; MAMDC1; c14_5286; MAMdomain-containing glycosylphosphatidylinositol anchor protein 2; MAM domaincontaining 1; MAMDC1; OTTHUMP00000028200; OTTHUMP00000179128; MAMdomain-containing protein 1; UNQ8188/PRO23197
Gene ID : 161357
mRNA Refseq : NM_182830
Protein Refseq : NP_878250
MIM : 611128
UniProt ID : Q7Z553
Chromosome Location : 14q21.2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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