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Recombinant Mouse Met Proto-Oncogene, Fc-tagged

Cat. No.: Met-730M
Product Overview: Recombinant Mouse Metprotein was expressed in Murine myeloma cell line with the Fc part of MouseIgG2A Glu98-Lys330 (C-terminus) and Met1-Asn929 (N-terminus).
Description: Met is aglycosylated receptor tyrosine kinase that plays a central role in epithelialmorphogenesis and cancer development. Met is synthesized as a single chainprecursor which undergoes cotranslational proteolytic cleavage. This generatesa mature Met that is a disulfide-linked dimer composed of a 50 kDaextracellular α chain and a 145 kDa transmembrane β chain.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Glu25 & Ser307
Molecular Weight: 96 &32 kDa
Activity: Measuredby its ability to bind recombinant mouse Met in a functional ELISA with anestimated KD < 0.2 nM.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 110-120kDa & 40-43 kDa, reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 200 μg/ mLin PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Met met proto-oncogene [ Musmusculus ]
Official Symbol: Met
Synonyms: Met; metproto-oncogene; HGF; HGFR; Par4; c-Met; AI838057; hepatocyte growth factorreceptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met;scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogenetyrosine kinase; EC 2.7.10.1; Met protein
Gene ID: 17295
mRNA Refseq: NM_008591
Protein Refseq: NP_032617
UniProt ID: P16056
Chromosome Location: 6 A2; 6 4.0 cM
Pathway: Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Axon guidance; Bacterial invasion ofepithelial cells; Cytokine-cytokine receptor interaction; DevelopmentalBiology; Endocytosis; Focal Adhesion; Focal adhesion; Malaria; Melanoma;Pathways in cancer; Renal cell carcinoma; Sema4D in semaphorin signaling;Semaphorin interactions
Function: ATP binding;beta-catenin binding; hepatocyte growth factor-activated receptor activity;kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding;phospholipase binding; protein complex binding; protein heterodimerizationactivity; protein kinase activity; protein tyrosine kinase activity; receptoractivity; transferase activity

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