"HS3ST1" Related Products

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Recombinant Human Heparan Sulfate (glucosamine) 3-O-Sulfotransferase 1, His-tagged

Cat. No.: HS3ST1-1970H
Product Overview: RecombinantHuman HS3ST1 protein was expressed in Chinese HamsterOvary cell line. Arg21-His307, with an N-terminal 6-Histag.
Description: Heparan sulfate is a highly sulfated polysaccharide that can befound on cell surface and within extracellular matrix. It is typicallycovalently attached to the protein core of proteoglycans, such as syndecansand glypicans. Heparin, on the other hand, can be considered as a highlysulfated version of heparan sulfate that is detached from the protein coreand is predominantly found in mast cells. Both heparin and heparan sulfatecontain disaccharide repeats of uronic acid and N-acetylglucosamineAnd are modified by the same sulfotransferases. The uronic acidresidues can be sulfated at 2-O position by heparan sulfate 2-O sulfotransferase(HS2ST). The N-acetylglucosamine residues can be sulfated at N, 3-O, and 6-O positionsby N-deacetylase/N-sulfotransferases (NDSTs), heparan sulfate 3-O sulfotransferases(HS3STs) and heparan sulfate 6-O sulfotransferases (HS6STs) respectively.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Supplied as a 0.2 umfiltered solution in TrisHCl and NaCl.
N-terminalSequence: His
MolecularWeight: 35 kDa
Activity: Measuredby its ability to transfer sulfate from PAPS to heparan sulfate. The specificactivity is > 4 pmoles/min/μg, as measured under the described conditions.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 38-50kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.
Gene Name: HS3ST1 heparan sulfate(glucosamine) 3-O-sulfotransferase 1 [ Homo sapiens ]
Official Symbol: HS3ST1
Synonyms: HS3ST1; heparan sulfate(glucosamine) 3-O-sulfotransferase 1; heparan sulfate glucosamine3-O-sulfotransferase 1; 3OST1; 3-OST-1; 3OST; EC 2.8.2.23; h3OST 1; h3-OST-1;Heparan sulfate 3 O sulfotransferase 1; Heparan sulfate D glucosaminyl 3 Osulfotransferase 1; Heparin glucosamine 3 O sulfotransferase; heparan sulfate3-O-sulfotransferase 1; heparin-glucosamine 3-O-sulfotransferase; heparansulfate D-glucosaminyl 3-O-sulfotransferase 1
Gene ID: 9957
mRNA Refseq: NM_005114
Protein Refseq: NP_005105
MIM: 603244
UniProt ID: O14792
Chromosome Location: 4p16
Pathway: Glycosaminoglycanbiosynthesis - heparan sulfate
Function: [heparansulfate]-glucosamine 3-sulfotransferase 1 activity; sulfotransferase activity;transferase activity

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