"C6orf25" Related Products

Recombinant Human Chromosome 6 Open Reading Frame 25, Fc-tagged

Cat. No.: C6orf25-5603H
Product Overview: Recombinant Human C6orf25protein was expressed in CHO with the Fc part of human IgG1 Pro100-Lys330(C-terminus) and Asn18-Gln142 (N-terminus).
Description: C6orf25 is a type Itransmembrane glycoprotein in the immunoglobulin superfamily that is encodedwithin the human class III major histocompatibility complex. It is expressedmainly on platelets, and has also been detected on megakaryocytes and thehuman cell line K562. Crosslinking of C6orf25 inhibits agoniststimulatedplatelet aggregation and activation. The 241 amino acid (aa) human C6orf25isotype B (G6bB) contains a 17 aa signal sequence, a 125 aa extracellulardomain with one Vtype Ig-like domain and one N-linked glycosylation site, a21 aa transmembrane sequence and a 78 aa cytoplasmic sequence with two ITIMinhibitory motifs and a SH3 binding site.
Source: Chinese HamsterOvary cell line, CHO-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Asn18
Molecular Weight: 40.0 kDa
Activity: Measuredby its binding ability in a functional ELISA. When 1 μg/mL of rhC6orf25/Fc is captured by a goat antihuman IgG Fc coated plate,the concentration of biotinylated heparin that produces 50% of the optimal bindingresponse is found to be approximately 10-40 ng/mL.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 45-55kDa, reducing conditions
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in PBS
Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under steril conditions after reconstitution.
Gene Name: C6orf25 chromosome 6 openreading frame 25 [ Homo sapiens ]
Official Symbol: C6orf25
Synonyms: C6orf25; chromosome6 open reading frame 25; G6b; NG31; MGC142279, MGC142281; protein G6b;immunoglobulin receptor; OTTHUMP00000029171; OTTHUMP00000029172; OTTHUMP00000029173;OTTHUMP00000029176; OTTHUMP00000029177; OTTHUMP00000215228;OTTHUMP00000215230
Gene ID: 80739
mRNA Refseq: NM_025260
Protein Refseq: NP_079536
MIM: 606520
UniProt ID: O95866
Chromosome Location: 6p21
Function: heparin binding;receptor activity

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