"CXCL17" Related Products

Recombinant Human Chemokine (C-X-C motif) Ligand 17

Cat. No. : CXCL17-436H
Product Overview : Recombinant Human CXCL17is expressed in E. coli, which has a molecule weight of 11.3 kDa. Leu24­ Leu119.
Description : Dendritic cell and monocytechemokine­like protein (DMC), also known as VEGF­correlated chemokine­1 (VCC­1)and CXCL17, is a novel secreted molecule that belongs to the intercrine alpha(or CXC) family of chemokines. It has no predicted N­glycosylation sites, so cleavageof a 22 amino acid (aa) signal sequence likely results in a mature human DMC of97 aa and 11 kDa. DMC expression is increased in endothelial cells when they areinduced to form tubes in vitro. Transgenic overexpression in NIH3T3 cells causesup­regulation of proteins such as VEGF and FGF basic, and increases cell growthrate and tumorigenicity. DMC and two other chemokines that play roles in angiogenesis,CXCL1/GRO and CXCL8/IL­8, show significantly correlated expression with that ofVEGF in primary lung, breast and esophageal tumors. DMC is therefore suggestedto play a role in tumor angiogenesis. Mature human DMC shares 73%, 71% and 64%amino acid sequence identity with bovine, mouse and rat DMC, respectively.
Source : E. coli­derived
Form : Lyophilized from a 0.2μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
N-terminal Sequence : Leu24
Molecular Weight : 11.3 kDa
Activity : Measured by its abilityto induce VEGF expression in mouse endothelial cells. The ED50 for this effectis typically 1 ­ 5 µg/mL.
Purity : >95%, by SDS­PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level : <1.0 EU per 1 μg ofthe protein by the LAL method.
Reconstitution : Reconstitute at 100μg/mL in PBS that containing at least 0.1% human or bovine serum albumin.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol : CXCL17
Gene Name : CXCL17 chemokine (C-X-C motif)ligand 17 [ Homo sapiens ]
Synonyms : CXCL17; chemokine (C-X-Cmotif) ligand 17; DMC; VCC1; Dcip1; VCC-1; UNQ473; MGC138300; VEGF co-regulatedchemokine 1; C-X-C motif chemokine 17; dendritic cell and monocyte chemokine-likeprotein
Gene ID : 284340
mRNA Refseq : NM_198477
Protein Refseq : NP_940879
MIM : 611387
UniProt ID : Q6UXB2
Chromosome Location : 19q13.2

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