"CRYGC" Related Products

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Recombinant Human Crystallin, Gamma C, His-tagged

Cat. No.: CRYGC-2396H
Product Overview: Recombinant humanCRYGC protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques
Description: Gamma-crystallin C, alsoknown as CRYGC, belongs to the beta/gamma-crystallin family. Mammalian lenscrystallins are divided into alpha, beta, and gamma families; beta and gammacrystallins are also considered as a superfamily. Gamma-crystallins are ahomogeneous group of highly symmetrical, monomeric proteins typically lackingconnecting peptides and terminal extensions. They are differentiallyregulated after early development. Four gamma-crystallin genes (gamma-Athrough gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) areorganized in a genomic segment as a gene cluster. Whether due to aging ormutations in specific genes, gamma-crystallins have been involved in cataractformation. Defects in CRYGC are a cause of cataract autosomal dominant (ADC)and cataract Coppock-like (CCL)
Form: Liquid. In 20 mMTris-HCl buffer, pH8.0, 10% glycerol, 2mM DTT, 200mM NaCl
Molecular Weight: 23.5kDa (198aa),confirmed by MALDI-TOF
Purity: > 95% by SDS -PAGE
Concentration: 1mg/ml (determinedby Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMGKITF YEDRAFQGRS YETTTDCPNL QPYFSRCNSI RVESGCWMLY ERPNYQGQQYLLRRGEYPDY QQWMGLSDSI RSCCLIPQTV SHRLRLYERE DHKGLMMELS EDCPSIQDRF HLSEIRSLHVLEGCWVLYEL PNYRGRQYLL RPQEYRRCQD WGAMDAKAGS LRRVVDLY
Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene name: CRYGCcrystallin, gamma C [ Homo sapiens ]
Official Symbol: CRYGC
Synonyms: CRYGC; crystallin, gamma C; CRYG3; gamma-crystallin C; CATARACT,VARIABLE ZONULAR PULVERULENT; CCL; CRGC_HUMAN; CRYG 3; Cryg 5; Cryg; CRYG3;CRYGC; Crystallin gamma 3; Crystallin gamma C; Gamma C crystallin; Gammacrystallin 2 1; Gamma crystallin 3; Gamma crystallin C; Gamma-C-crystallin;Gamma-crystallin 2-1; Gamma-crystallin 3; Gamma-crystallin C; Gammab cry;Len; OTTHUMP00000163869; gamma-C-crystallin; gamma-crystallin 3; crystallin,gamma-3; gamma-crystallin 2-1; CCL;
Gene ID: 1420
mRNA Refseq: NM_020989
Protein Refseq: NP_066269
Uniprot ID: P07315
Chromosome Location: 2q33-q35
Function: protein binding; structural constituent of eye lens

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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