Recombinant Human HTR2A, GST-tagged

• Cat.No.: HTR2A-1872H
• Product Overview: RecombinantHuman HTR2A, expressed as gst-tagged fusion protein by E.Coli is purified byGSH-sepharose.

Specification

• Cat. No.: HTR2A-1872H
• Description: This gene encodes one ofthe receptors for serotonin, a neurotransmitter with many roles. Mutations inthis gene are associated with susceptibility to schizophrenia andobsessive-compulsive disorder, and are also associated with response to theantidepressant citalopram in patients with major depressive disorder (MDD).MDD patients who also have a mutation in intron 2 of this gene show asignificantly reduced response to citalopram as this antidepressantdownregulates expression of this gene. Multiple transcript variants encodingdifferent isoforms have been found for this gene
• Source: E. coli.
• Storage buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl,pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HTR2A 5-hydroxytryptamine(serotonin) receptor 2A, G protein-coupled [ Homo sapiens ]
• Synonyms: 5-hydroxytryptamine(serotonin) receptor 2A;G protein-coupled;HTR2; 5-HT2A;-hydroxytryptaminereceptor 2A;5-hydroxytryptaminereceptor 2A;5-HT-2A;5-HT2 receptor;serotonin5-HT-2A receptor; 5-hydroxytryptamine (serotonin) receptor 2A; 5-HT2A; Serotonin receptor2A; 5-HT-2; 5 HT 2; 5HT 2A; 5 HT2 receptor; 5 HT2A; 5 hydroxytryptamine receptor 2A; 5-HT-2;5-HT-2A; 5-hydroxytryptamine 2A receptor; 5-hydroxytryptamine receptor 2A;5HT2A_HUMAN; HTR 2; HTR2; HTR2A; OTTHUMP00000018378; HTR2
• Gene ID: 3356
• mRNA Refseq: NM_000621
• Protein Refseq: NP_000612
• MIM: 182135
• UniProt ID: P28223
• Chromosome Location: 13q14-q21
• Pathway: Adherensjunction; Calciumsignaling pathway; Calciumsignaling pathway; Class A/1(Rhodopsin-like receptors); G alpha (q)signalling events; GPCRdownstream signaling, GPCR ligandbinding; GPCRs; GPCRs
• Function: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-aminebinding; G-proteincoupled receptor activity; drugbinding;hosphatidylinositolphospholipase C activity;receptoractivity;serotoninbinding;serotoninreceptor activity;signaltransducer activity