"CDC26" Related Products

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Recombinant Human CDC26, His-tagged

Cat. No.: CDC26-3554H
Product Overview: Recombinant humanCDC26 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.
Description: CDC26,also known as ANAPC12, APC12, belongs to the CDC26 family which orchestrates progressionthrough mitosis by decorating cell-cycle regulators with ubiquitin chains.This protein is component of the anaphase promoting complex/cyclosome (APC/C),a cell cycle-regulated E3 ubiquitin ligase that controls progression throughmitosis and the G1 phase of the cell cycle. The APC/C complex acts bymediating ubiquitination and subsequent degradation of target proteins.
Form: Liquid. 20mM Tris-HClbuffer (pH8.0) containing 40% glycerol, 0.1M NaCl.
Molecular Weight: 11.9 kDa (105 aa), confirmed by MALDI-TOF.
Purity: > 90%by SDS - PAGE
Concentration: 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHH SSGLVPRGSH MLRRKPTRLELK LDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM INDRIGYKPQ PKPNNRSSQFGSLEF
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CDC26 cell division cycle 26homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol: CDC26
Synonyms: CDC26; cell division cycle 26 homolog (S.cerevisiae); APC12; ANAPC12; C9orf17; anaphase-promoting complex subunitCDC26; anaphase promoting complex subunit 12; anaphase-promoting complexsubunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphasepromoting complex; OTTHUMP00000021952
Gene ID: 246184
mRNA Refseq: NM_139286
Protein Refseq: NP_644815
UniProt ID: Q8NHZ8
Chromosome Location: 9q32
Pathway: APC/C complex; APC/C-mediated degradationof cell cycle proteins; Adaptive Immune System; Antigen processing:Ubiquitination & Proteasome degradation; Cell Cycle; Class I MHC mediatedantigen processing & presentation; HTLV-I infection; Immune System;Mitotic Spindle Checkpoint; Oocyte meiosis; Phosphorylation of the APC/C;Progesterone-mediated oocyte maturation; Regulation of mitotic cell cycle;Ubiquitin mediated proteolysis
Function: protein binding

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