Rabbit Anti-Human CD27 Molecule Monoclonal Antibody

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Rabbit Anti-Human CD27 Molecule Monoclonal Antibody

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Cat.No. : CAB11497RH
Product Overview : Rabbit monoclonal antibody to human CD27 molecule.
Antigen Description : CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, and during which, adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling processes. In addition, a proapoptotic protein named SIVA, is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.
Specificity : Human CD27 / TNFRSF7. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. Mouse CD27, Human TNFRSF8 / CD30, Human 4-1BB, Human CD40, Human DR6, Human FAS, Human HVEM / TNFRSF14, Human TNFRI, Human TNFRII, Human BAFF, Human RELT, Mouse HVEM, Mouse FAS, Rat FAS, Human cell lysate (293 cell line).
Immunogen : Recombinant Human CD27 / TNFRSF7 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Clone : 037
Applications : Western Blot; ELISA
Dilution : Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Human CD27 in WB. Using a DAB detection system, the detection limit for Human CD27 is approximately 1 ng/lane under non-reducing. Use of this antibody under reducing conditions is not recommended.Direct ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect Human CD27. The detection limit for Human CD27 is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human CD27 / TNFRSF7.
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : CD27 CD27 molecule [ Homo sapiens ]
Official Symbol : CD27
Synonyms : CD27; CD27 molecule; TNFRSF7,tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14; TNFRSF7; MGC20393;
Gene ID : 939
mRNA Refseq : NM_001242
Protein Refseq : NP_001233
MIM : 186711
UniProt ID : P26842
Chromosome Location : 12p13
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; receptor activity; transmembrane signaling receptor activity;

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