Recombinant Human Cell Division Cycle Associated 8, His-tagged CDCA8-3526H

Recombinant Human Cell Division Cycle Associated 8, His-tagged

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Recombinant Human Cell Division Cycle Associated 8, His-tagged

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Cat. No. : CDCA8-3526H
Product Overview : Recombinant human CDCA8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (19-280aa).
Description : CDCA8, also known as Borealin, is a component of the chromosomal passenger complex (CPC). The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.In the complex, CDCA8 protein may be required to direct the CPC to centromeric DNA. Deletion of CDCA8 delays mitotic progression and causes kinetochore-spindle to mis-attach.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT,50% glycerol, 1mM EDTA, 0.2M NaCl
Molecular Weight : 31.6 kDa (283aa)confirmed by MALDI-TOF
Purity : > 90% by SDS - PAGE
Concentration : 0.25 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MRKLASFLKD FDREVEIRIK QIESDRQNLL KEVDNLYNIE ILRLPKALRE MNWLDYFALG GNKQALEEAATADLDITEIN KLTAEAIQTP LKSAKTRKVI QVDEMIVEEE EEEENERKNL QTARVKRCPP SKKRTQSIQG KGKGKRSSRA NTVTPAVGRLEVSMVKPTPG LTPRFDSRVF KTPGLRTPAA GERIYNISGN GSPLADSKEI FLTVPVGGGE SLRLLASDLQ RHSIAQLDPE ALGNIKKLSNRLAQICSSIR THK
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name : CDCA8 cell division cycle associated 8 [ Homo sapiens ]
Synonyms : CDCA8; BOR; DasraB; MESRGP; BOREALIN; FLJ10468; FLJ12042; borealin; Dasra B; dasra-B; hDasra-B; OTTHUMP00000004514; cell division cycle-associated protein 8; pluripotent embryonic stem cell-related gene 3 protein
Gene ID : 55143
mRNA Refseq : NM_018101
Protein Refseq : NP_060571
MIM : 609977
UniProt ID : Q53HL2
Chromosome Location : 1p34.3
Function : protein binding

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