"HDAC10" Related Products


Recombinant Human HDAC10 (Active), GST-tagged

Cat.No. : HDAC10-1354H
Product Overview : Recombinant human HDAC10 (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors. Therefore, HDAC10 plays a role in transcriptional repression. HDAC10 interacts with HDAC3 in co-transfected embryonic kidney cells. Deletion analysis indicates that both the N- and C-terminal domains of HDAC10 bound HDAC3 independently.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 120 RLU/min/ng
Molecular Mass : ~77 kDa
Protein length : 1-482 aa
Purity : >80%
Applications : HDAC Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : HDAC10 histone deacetylase 10 [ Homo sapiens ]
Official Symbol : HDAC10
Synonyms : HDAC10; histone deacetylase 10; DKFZP761B039; HD10; MGC149722; DKFZp761B039;
Gene ID : 83933
mRNA Refseq : NM_001159286
Protein Refseq : NP_001152758
MIM : 608544
UniProt ID : Q969S8
Chromosome Location : 22q13.31
Pathway : NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem;
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; protein binding; protein deacetylase activity;

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