Recombinant Human BAD, GST-tagged
Cat.No. : | BAD-6973H |
Product Overview : | Recombinant full-length human BAD was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | BAD is a member of the BCL-2 family of proteins that are known to be regulators of programmed cell death. BAD is a pro-apoptotic protein that forms a heterodimer complex with BCL-xL and BCL-2 which reverses the prosurvival activity of these proteins. The proapoptotic activity of BAD is regulated through its phosphorylation and this inhibits the pro-apoptosis function of BAD. Protein kinases such as AKT, RAF and RSK1 can phosphorylate BAD and RSK1-induced phosphorylation of BAD at ser112 suppresses BAD-mediated apoptosis in neurons. BAD inhibits G(1) to S phase transition in MCF7 breast cancer cells and overexpression of BAD inhibits cell growth as well as cyclin D1 expression. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25m DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~47 kDa |
Protein length : | Full length |
Purity : | >85% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | BAD BCL2-associated agonist of cell death [ Homo sapiens ] |
Official Symbol : | BAD |
Synonyms : | BAD; BCL2-associated agonist of cell death; bcl2 antagonist of cell death; BBC2; BCL2L8; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter; |
Gene ID : | 572 |
mRNA Refseq : | NM_004322 |
Protein Refseq : | NP_004313 |
MIM : | 603167 |
UniProt ID : | Q92934 |
Chromosome Location : | 11q13.1 |
Pathway : | AKT phosphorylates targets in the cytosol, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Alpha-synuclein signaling, organism-specific biosystem; |
Function : | cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; |
Products Types
◆ Recombinant Protein | ||
BAD-589R | Recombinant Rat BAD Protein, His (Fc)-Avi-tagged | +Inquiry |
Bad-689M | Recombinant Mouse Bad Protein, MYC/DDK-tagged | +Inquiry |
BAD-333R | Recombinant Rhesus Macaque BAD Protein, His (Fc)-Avi-tagged | +Inquiry |
BAD-949M | Recombinant Mouse BAD Protein, His (Fc)-Avi-tagged | +Inquiry |
BAD-419H | Recombinant Human BAD Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
BAD-8529HCL | Recombinant Human BAD 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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