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Recombinant Human PTPRM , GST-tagged

Cat.No. : PTPRM-7017H
Product Overview : Recombinant human PTPRM (764-1452) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~110 kDa
Protein length : 764-1452 aa
Purity : >90%
Applications : Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.2 μg/μl
Gene Name : PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ]
Official Symbol : PTPRM
Synonyms : PTPRM; protein tyrosine phosphatase, receptor type, M; PTPRL1; receptor-type tyrosine-protein phosphatase mu; hR PTPu; RPTPU; protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; RPTPM; hR-PTPu; R-PTP-MU; MGC166994;
Gene ID : 5797
mRNA Refseq : NM_001105244
Protein Refseq : NP_001098714
MIM : 176888
UniProt ID : P28827
Chromosome Location : 18p11.2
Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Nectin adhesion pathway, organism-specific biosystem;
Function : cadherin binding; hydrolase activity; protein binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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