Recombinant Human CTSS, His-tagged

• Cat.No.: CTSS-7251H

Specification

• product overview: Recombinant human CTSS protein, fused to His-tag at N-terminus, was expressed in E.coli.
• description: Cathepsin S, also known as CTSS, is a member of the peptidase C1 family. This protein is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS can function as an elastase over a broad pH range in alveolar macrophages.
• source: E. coli
• species: Human
• tag: His
• form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• molecular mass: 38.1 kDa (336aa)
• protein length: 17-331aa
• aa sequence: MGSSHHHHHH SSGLVPRGSH MQLHKDPTLD HHWHLWKKTY GKQYKEKNEE AVRRLIWEKN LKFVMLHNLE HSMGMHSYDL GMNHLGDMTS EEVMSLMSSL RVPSQWQRNI TYKSNPNWIL PDSVDWREKG CVTEVKYQGS CGACWAFSAV GALEAQLKLK TGKLVSLSAQ NLVDCSTEKY GNKGCNGGFM TTAFQYIIDN KGIDSDASYP YKAMDQKCQY DSKYRAATCS KYTELPYGRE DVLKEAVANK GPVSVGVDAR HPSFFLYRSG VYYEPSCTQN VNHGVLVVGY GDLNGKEYWL VKNSWGHNFG EEGYIRMARN KGNHCGIASF PSYPEI
• purity: >85% by SDS - PAGE
• applications: SDS-PAGE
• storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• concentration: 1 mg/ml

Gene Information

• gene name: CTSS cathepsin S [ Homo sapiens ]
• official symbol: CTSS
• synonyms: CTSS; cathepsin S; MGC3886; FLJ50259
• Gene ID: 1520
• mrna refseq: NM_001199739
• protein refseq: NP_001186668
• mim: 116845
• uniprot id: P25774
• chromosome location: 1q21
• pathway: Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
• function: cysteine-type endopeptidase activity; peptidase activity