Active Recombinant Human Growth Hormone Releasing Hormone
Cat.No. : | GHRH-288H |
Product Overview : | Growth Hormone Releasing Hormone Human Synthetic is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3358.9 Dalton. Corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone consisting of 44 amino acid residues. The GHRH is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GHRH-288H |
Description : | Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acidpeptide hormoneproduced in the arcuate nucleusof the hypothalamus. GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary glandwhere it stimulates growth hormone (GH) secretion. GHRH also stimulates the production of GH. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleepdirectly. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | The GHRH peptide (1mg/ml) was lyophilized after extensive dialyses against 1.7 mg sodium phosphate buffer (0.1 mg sodium phosphate monobasic & 1.6 mg sodium phosphate dibasic). |
Purity : | Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Bio-activity : | GHRH increases plasma growth hormone concentrations by directly stimulating the anterior pituitary gland to release natural human growth hormone. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized GHRH in sterile 18Mμ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. The GHRH is also soluble in 1% Acetic acid at a concentration of >1mg/ml to give a clear, colorless solution. |
Amino acid sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Tyr-Ala-Asp-Ala-Ile. |
Storage : | Lyophilized Growth Hormone Releasing Hormone although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHRF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Pathways : | Neuroactive ligand-receptor interaction; Signaling by GPCR |
Publication : |
Neuron-specific Mafb knockout causes growth retardation accompanied by an impaired GH/IGF-I axis (2019)
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Gene Name : | GHRH growth hormone releasing hormone [ Homo sapiens ] |
Official Symbol : | GHRH |
Synonyms : | GHRH; growth hormone releasing hormone; OTTHUMP00000030915; growth hormone-releasing factor; growth hormone-releasing hormone; sermorelin; somatocrinin; somatoliberin; somatorelin; GRF; INN; GHRF; MGC119781 |
Gene ID : | 2691 |
mRNA Refseq : | NM_001184731 |
Protein Refseq : | NP_001171660 |
MIM : | 139190 |
UniProt ID : | P01286 |
Chromosome Location : | 20q11.2 |
Function : | growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding |
Products Types
◆ Recombinant Protein | ||
GHRH-3550M | Recombinant Mouse GHRH Protein, His (Fc)-Avi-tagged | +Inquiry |
GHRH-523S | Recombinant Sheep GHRH Protein (1-44 aa), GST-tagged | +Inquiry |
GHRH-4888H | Recombinant Human GHRH Protein, GST-tagged | +Inquiry |
GHRH-2185R | Recombinant Rat GHRH Protein, His (Fc)-Avi-tagged | +Inquiry |
GHRH-13251H | Recombinant Human GHRH, His-tagged | +Inquiry |
◆ Native Protein | ||
GHRH-37H | Active Native Human GHRH | +Inquiry |
◆ Lysates | ||
GHRH-704HCL | Recombinant Human GHRH cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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