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Recombinant Human Cathepsin K

Cat. No.: CTSK-1659H
Product Overview: Recombinant human CTSK is a 35.1 kDa homodimeric protein consisting of 99 amino acid polypeptide domain.
Description: CTSK is a member of the papain cysteine proteinase family and has been identified as the predominant proteinase responsible for the resorption of the bone matrix. The enzyme cleaves proteins such as collagen type I, collagen type II and osteonectin and therefore plays a role in bone remodeling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis.
Molecular Weight: 35.1 kDa
Source: E. Coli
Species: Human
Form: Liquid (25 mM Tris pH 8.0, 500 mM NaCl).
Appearance: Liquid
Purity: ≥95% by SDS-PAGE
Storage: Procathepsin K can be aliquoted and stored at -80°C. Repeated freeze-thaw cycles must be avoided.
Gene Name: CTSK cathepsin K [ Homo sapiens ]
Official Symbol: CTSK
Synonyms: CTSK; cathepsin K; CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2; MGC23107; cathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2; OTTHUMP00000032938
Gene ID: 1513
mRNA Refseq: NM_000396
Protein Refseq: NP_000387
MIM: 601105
UniProt ID: P43235
Chromosome Location: 1q21
Pathway: Lysosome; Osteoclast Signaling; Osteoclast differentiation; Rheumatoid arthritis; Toll-like receptor signaling pathway
Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity

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