"CDK4" Related Products


Recombinant Human Cyclin-Dependent Kinase 4, GST-tagged

Cat. No. : CDK4-1000H
Product Overview : Recombinant full-length human CDK4 was expressed in E. coli cells using a N-terminal GST tag.
Description : CDK4 is a member of the cyclin-dependent protein kinases and is involved in the control of cell proliferation during the G1 phase of the cell cycle. CDK4 forms a complex with the D-type cyclins which regulate its activity. CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2. CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. Pharmacologic inactivation of CDC37/HSP90 function leads to reduced stability of CDK4. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2.
Applications : Kinase Assay; Western Blot
Molecular Weight : 57 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity : > 80 %
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70°C For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : ATF-2 transcription factor network; B Cell Receptor Signaling Pathway; Bladder cancer; Calcineurin-regulated NFAT-dependent transcription in lymphocytes; Cell Cycle; Cell cycle; Chronic myeloid leukemia; Cyclin D associated events in G1; Diabetes pathways; FOXM1 transcription factor network; G1 Phase; G1 to S cell cycle control; Glioma; HTLV-I infection; IL-7 Signaling Pathway
Rendering based on PDB 1LD2. :

Gene Name : CDK4 cyclin-dependent kinase 4 [ Homo sapiens ]
Official Symbol : CDK4
Synonyms : CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; MGC14458; Cyclin-dependent kinase 4; EC; Cell division protein kinase 4; cell division kinase 4; melanoma cutaneous malignant, 3
Gene ID : 1019
mRNA Refseq : NM_000075
Protein Refseq : NP_000066
MIM : 123829
UniProt ID : P11802
Chromosome Location : 12q14
Function : ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; protein kinase activity

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