"CDK5" Related Products


Recombinant Human Cyclin-Dependent Kinase 5, GST-tagged

Cat. No. : CDK5-1001H
Product Overview : Recombinant full-length human CDK5 was expressed in E. coli cells using a N-terminal GST tag.
Description : CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
Applications : Kinase Assay; Western Blot
Molecular Weight : 58 kDa
Expression System : E. coli
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity : > 90 %
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Alzheimer" s disease; Axon guidance; CRMPs in Sema3A signaling; DARPP-32 events; EPHA forward signaling; Factors involved in megakaryocyte development and platelet production; Glucocorticoid receptor regulatory network; Hemostasis; IL-6 Signaling Pathway; Lissencephaly gene (LIS1) in neuronal migration and development; Nicotine Activity on Dopaminergic Neurons; Opioid Signalling; Reelin signaling pathway; Semaphorin interactions; Trk receptor signaling mediated by the MAPK pathway
PDB rendering based on1h41. :

Gene Name : CDK5 cyclin-dependent kinase 5 [ Homo sapiens ]
Official Symbol : CDK5
Synonyms : CDK5; cyclin-dependent kinase 5; PSSALRE; cyclin-dependent kinase 5; OTTHUMP00000212917; OTTHUMP00000212939; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; Cyclin-dependent kinase 5; EC; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene ID : 1020
mRNA Refseq : NM_001164410
Protein Refseq : NP_001157882
MIM : 123831
UniProt ID : Q00535
Chromosome Location : 7q36
Function : ATP binding; ErbB-2 class receptor binding; acetylcholine receptor activator activity; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity

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