Recombinant Human Cyclin-Dependent Kinase 5, GST-tagged

• Cat.No.: CDK5-1001H
• Product Overview: Recombinant full-length human CDK5 was expressed in E. coli cells using a N-terminal GST tag.

Specification

• Cat. No.: CDK5-1001H
• Description: CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 58 kDa
• Expression System: E. coli
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
• Purity: > 90 %
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Alzheimer" s disease; Axon guidance; CRMPs in Sema3A signaling; DARPP-32 events; EPHA forward signaling; Factors involved in megakaryocyte development and platelet production; Glucocorticoid receptor regulatory network; Hemostasis; IL-6 Signaling Pathway; Lissencephaly gene (LIS1) in neuronal migration and development; Nicotine Activity on Dopaminergic Neurons; Opioid Signalling; Reelin signaling pathway; Semaphorin interactions; Trk receptor signaling mediated by the MAPK pathway

Gene Information

• Gene Name: CDK5 cyclin-dependent kinase 5 [ Homo sapiens ]
• Official Symbol: CDK5
• Synonyms: CDK5; cyclin-dependent kinase 5; PSSALRE; cyclin-dependent kinase 5; OTTHUMP00000212917; OTTHUMP00000212939; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit; Cyclin-dependent kinase 5; EC 2.7.11.22; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
• Gene ID: 1020
• mRNA Refseq: NM_001164410
• Protein Refseq: NP_001157882
• MIM: 123831
• UniProt ID: Q00535
• Chromosome Location: 7q36
• Function: ATP binding; ErbB-2 class receptor binding; acetylcholine receptor activator activity; cyclin-dependent protein kinase activity; kinase activity; nucleotide binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity