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Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A, GST-tagged

Cat.No. : CDKN1A-4837H
Product Overview : Recombinant full-length human CDKN1A was expressed in E. coli cells using a N-terminal GST tag.
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  • Gene Information
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Cat. No. : CDKN1A-4837H
Description : CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A) regulates cell cycle progression, terminal differentiation, and apoptosis. CDKN1A was shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinase (CDK) activity. DNA damage leads to increased expression of CDKN1A in cyclin E-containing complexes and to an associated decrease in cyclin-dependent kinase activity. CDKN1A is a critical downstream effector in the p53-specific pathway of growth control in mammalian cells.
Applications : Kinase Assay; Western Blot
Molecular Weight : 46 kDa
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : E. coli
Purity : > 80 %
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : AKT phosphorylates targets in the cytosol; AMPK signaling; Adipogenesis; Alpha6-Beta4 Integrin Signaling Pathway;Angiopoietin receptor Tie2-mediated signaling; Bladder cancer; C-MYB transcription factor network; Cell Cycle; Cyclin D associated events in G1; Cyclin E associated events during G1/S transition; DNA Replication; Direct p53 effectors; E2F transcription factor network; ErbB signaling pathway; G1 to S cell cycle control; G1/S DNA Damage Checkpoints; G1/S Transition
Gene Name : CDKN1A cyclin-dependent kinase inhibitor 1A [ Homo sapiens ]
Official Symbol : CDKN1A
Synonyms : CDKN1A; cyclin-dependent kinase inhibitor 1A; P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; OTTHUMP00000016297; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6; cyclin-dependent kinase inhibitor 1A (p21, Cip1); Cyclin-dependent kinase inhibitor 1; Melanoma differentiation-associated protein 6
Gene ID : 1026
mRNA Refseq : NM_000389
Protein Refseq : NP_000380
MIM : 116899
UniProt ID : P38936
Chromosome Location : 6q21.2
Function : cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase inhibitor activity; kinase activity; metal ion binding; protein binding; protein kinase inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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