Recombinant Human Cofilin 1 (non-muscle), His-tagged CFL1-1580H

Recombinant Human Cofilin 1 (non-muscle), His-tagged

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Cat. No. :	CFL1-1580H
Product Overview :	Recombinant full-length human CFL1 was expressed in E. coli cells using an N-terminal His tag.
Description :	Cofilin 1 (non-muscle), also known as CFL1, is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. CFL1 processed proteins are most probably produced by HIV-1 protease digestion.
Applications :	Western Blot
Molecular Weight :	23 kDa
Expression System :	E. coli
Species :	Human
Form :	Recombinant protein stored in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 2 mM DTT, 25 % glycerol.
Purity :	> 95 %
Concentration :	0.2 ug/ul
Sequences :	Full-lengt h
Storage :	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways :	Axon guidance; CDC42 signaling events; CXCR4-mediated signaling events; Fc gamma R-mediated phagocytosis; Formation of Platelet plug; G13 Signaling Pathway; Hemostasis; Pertussis; Platelet Activation; RAC1 signaling pathway; Regulation of Actin Cytoskeleton; RhoA signaling pathway; Sema3A PAK dependent Axon repulsion; Semaphorin interactions
PDB rendering based on 1q8g. :

Gene Name :	CFL1 cofilin 1 (non-muscle) [ Homo sapiens ]
Official Symbol :	CFL1
Synonyms :	CFL1; cofilin 1 (non-muscle); CFL; cofilin-1; p18; OTTHUMP00000233679; OTTHUMP00000233680; OTTHUMP00000233681; OTTHUMP00000233682; OTTHUMP00000233740; OTTHUMP00000233741; OTTHUMP00000233742; 18 kDa phosphoprotein; Cofilin-1, non-muscle isoform; Cofilin-1
Gene ID :	1072
mRNA Refseq :	NM_005507
Protein Refseq :	NP_005498
MIM :	601442
UniProt ID :	P23528
Chromosome Location :	11q13
Function :	actin binding; protein binding