"CREBBP" Related Products


Recombinant Human CREB Binding Protein, GST-tagged

Cat. No.: CREBBP-1581H
Product Overview: Recombinant human CREBBP (518-1207; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: CREBBP has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. CREBBP expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. CREBBP plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus.
Applications: Western Blot
Molecular Weight: 140 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity: > 90 %
Concentration: 0.1 ug/ul
Sequences: 518-1207
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins
Gene Name: CREBBP CREB binding protein [ Homo sapiens ]
Official Symbol: CREBBP
Synonyms: CREBBP; CREB binding protein; CBP; RSTS; KAT3A; Rubinstein-Taybi syndrome; RTS; CREB-binding protein; OTTHUMP00000159801; NP_001073315.1; EC; NP_004371.2
Gene ID: 1387
mRNA Refseq: NM_004380
Protein Refseq: NP_004371
MIM: 600140
UniProt ID: Q92793
Chromosome Location: 16p13.3
Function: MyoD binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; p53 binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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