"CSNK1E" Related Products

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Recombinant Human Casein Kinase 1, Epsilon, GST-tagged

Cat. No.: CSNK1E-1007H
Product Overview: Full length recombinant human CSNK1E was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: CSNK1E is a member of the CSNK1E family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CSNK1E is a regulator of Yes-associated protein (YAP) transcription coactivator which is a key regulator of organ size and a candidate human oncogene. CSNK1E is activated by CCK2R and this then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CSNK1E can phosphorylate topoisomerase (topo) IIalpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs.
Applications: Kinase Assay; Western Blot
Molecular Weight: 72 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity: 46 nmol/min/mg
Purity: > 75 %
Concentration: 0.1 ug/ul
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Canonical Wnt signaling pathway; Cell Cycle; Centrosome maturation; Circadian Clock; Circadian rhythm – mammal; Circadian rhythm pathway; FoxO family signaling; G2/M Transition; Hedgehog signaling events mediated by Gli proteins; Hedgehog signaling pathway; Loss of Nlp from mitotic centrosomes; Mitotic G2-G2/M phases; Recruitment of mitotic centrosome proteins and complexes; Wnt Signaling Pathway; p53 pathway
Gene Name: CSNK1E casein kinase 1, epsilon [ Homo sapiens ]
Official Symbol: CSNK1E
Synonyms: CSNK1E; casein kinase 1, epsilon; HCKIE; MGC10398; casein kinase I isoform epsilon; CKIe; CKI-epsilon; OTTHUMP00000199211; OTTHUMP00000199212; OTTHUMP00000199213; OTTHUMP00000199217; NP_001885.1; EC 2.7.11.1; NP_689407.1
Gene ID: 1454
mRNA Refseq: NM_001894
Protein Refseq: NP_001885
MIM: 600863
UniProt ID: P49674
Chromosome Location: 22q13.1
Function: ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

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