"DCLK1" Related Products


Recombinant Human Doublecortin-like Kinase 1, GST-tagged

Cat. No. : DCLK1-1009H
Product Overview : Full-length recombinant human DCLK1 was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Description : DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCLK1 is a microtubule-associated kinase that can undergo autophosphorylation. DCLK1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCLK1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.
Applications : Kinase Assay; Western Blot
Molecular Weight : 110 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, ph 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Specific Activity : 3.4 nmol/min/mg
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
PDBrendering based on 1mfw. :

Gene Name : DCLK1 doublecortin-like kinase 1 [ Homo sapiens ]
Official Symbol : DCLK1
Synonyms : DCLK1; doublecortin-like kinase 1; CL1; DCLK; CLICK1; DCDC3A; DCAMKL1; KIAA0369; serine/threonine-protein kinase DCLK1; OTTHUMP00000018250; OTTHUMP00000018251; OTTHUMP00000018252; doublecortin and CaM kinase-like 1; doublecortin-like and CAM kinase-like 1; doublecortin domain-containing protein 3A; EC=
Gene ID : 9201
mRNA Refseq : NM_004734
Protein Refseq : NP_004725
MIM : 604742
UniProt ID : O15075
Chromosome Location : 13q13.3
Function : ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein activity

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