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Recombinant Human Cyclin G1, His-tagged

Cat.No. : CCNG1-1331H
Product Overview : Recombinant human CCNG1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
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Cat. No. : CCNG1-1331H
Description : CCNG1, also known as cyclin-G1, is a member of the cyclin family and contains the cyclin box. It may play a role in growth regulation and be associated with G2/M phase arrest in response to DNA damage. It may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.
Form : Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 5 mM DTT, 50% glycerol, 0.2 M NaCl.
Molecular Weight : 36.2 kDa (315 aa) confirmed by MALDI-TOF
Purity : > 85 % by SDS-PAGE
Concentration : 0.25 mg/ml (determined by Bradford assay)
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MIEVLTTTDS QKLLHQLNAL LEQESRCQPK VCGLRLIESA HDNGLRMTAR LRDFEVKDLL SLTQFFGFDT ETFSLAVNLL DRFLSKMKVQ PKHLGCVGLS CFYLAVKSIE EERNVPLATD LIRISQYRFT VSDLMRMEKI VLEKVCWKVK ATTAFQFLQL YYSLLQENLP LERRNSINFE RLEAQLKACH CRIIFSKAKP SVLALSIIAL EIQAQKCVEL TEGIECLQKH SKINGRDLTF WQELVSKCLT EYSSNKCSKP NVQKLKWIVS GRTARQLKHS YYRITHLPTI PEMVP
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Direct p53 effectors; p53 pathway; p53 signaling pathway
Gene Name : CCNG1 cyclin G1 [ Homo sapiens ]
Official Symbol : CCNG1
Synonyms : CCNG1; cyclin G1; CCNG; OTTHUMP00000223693; OTTHUMP00000223697; OTTHUMP00000223691; OTTHUMP00000223692; OTTHUMP00000223690; cyclin-G; Cyclin-G; CYCG1
Gene ID : 900
mRNA Refseq : NM_004060
Protein Refseq : NP_004051
MIM : 601578
UniProt ID : P51959
Chromosome Location : 5q32-q34
Function : Protein domain specific binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What potential does CCNG1 have as a therapeutic target in cancer treatment? 02/16/2021

Targeting CCNG1 in cancer therapy could help control tumor growth by affecting cell cycle dynamics.

What is the impact of CCNG1 dysregulation in the progression of various cancers? 01/30/2021

Dysregulated CCNG1 expression is linked with the advancement of various cancers due to its role in cell cycle control.

What is the primary function of CCNG1 in cell cycle regulation? 11/09/2020

CCNG1, as a cyclin, regulates the cell cycle, particularly the transition between phases.

How does CCNG1 influence cellular senescence and aging? 04/19/2020

It contributes to cellular senescence by influencing cell cycle arrest mechanisms.

How do genetic alterations in CCNG1 affect its role in cell cycle regulation and cancer development? 11/06/2019

Mutations in CCNG1 can lead to aberrant cell cycle progression, potentially resulting in cancer.

How does CCNG1 interact with other cell cycle regulators and signaling pathways? 08/24/2018

CCNG1 works in tandem with other cell cycle proteins and signaling pathways to regulate cell division.

What role does CCNG1 play in DNA damage response and repair mechanisms? 06/20/2017

CCNG1 plays a role in DNA damage response, helping to maintain genomic stability.

Customer Reviews (3)

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Reviews
12/10/2022

    Consistently delivers, boosts research productivity.

    10/22/2020

      Integral to our research, dependable analysis.

      08/26/2018

        Streamlines our experiments, saving time and effort.

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